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      ["title"]=>
      string(54) "How more inclusive lab meetings lead to better science"
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      string(707) "Journal Reference: Nigel Golden, Kadambari Devarajan, Cathleen Balantic, Joseph Drake, Michael T. Hallworth, Toni Lyn Morelli. Ten simple rules for productive lab meetings. PLOS Computational Biology, 2021; 17 (5): e1008953 DOI: 10.1371/journal.pcbi.1008953 The word “scientist” might conjure images of lab-coated researchers tending bubbling beakers or building supercomputers, but an enormous amount of scientific work takes ... Read more"
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Journal Reference:

  1. Nigel Golden, Kadambari Devarajan, Cathleen Balantic, Joseph Drake, Michael T. Hallworth, Toni Lyn Morelli. Ten simple rules for productive lab meetings. PLOS Computational Biology, 2021; 17 (5): e1008953 DOI: 10.1371/journal.pcbi.1008953

The word “scientist” might conjure images of lab-coated researchers tending bubbling beakers or building supercomputers, but an enormous amount of scientific work takes place around a conference table during weekly group meetings. “There is plenty of good research showing that diversity and inclusion make the science itself better,” says Kadambari Devarajan, one of the paper’s co-lead authors and a graduate student in organismic and evolutionary biology as well as environmental conservation. Such diversity and inclusion starts with the structure of the lab meeting itself. Kadambari and her colleagues developed a set of ten guiding principles that help to cultivate lab environments that are inclusive as well productive lab environment, which range from the practical — “Rule 2: Identify roles and rules” and “Rule 6: Manage conflict” — to the interpersonal: “Rule 5: Be respectful and practice civility” and “Rule 9: Be aware of biases.”

Each of the ten rules came out of the team’s own working practice, honed by years of use, in Toni Lyn Morelli’s lab, whose members hail from countries around the globe and are in various stages of their careers. Morelli (Northeast Climate Adaptation Science Center and US Geological Survey), a co-author of the paper and a research ecologist affiliated with the environmental conservation department as well as the organismic and evolutionary biology program, notes that though diversity and inclusion are of interest far beyond the realm of science, there’s not always a practical guide to go by. “How does one create a diverse and inclusive lab that enables all members to bring their whole selves? What week-to-week actions can reinforce the sense of community and increase an individual’s, and thus the whole group’s, productivity?” She hopes that these guidelines can act as inspiration for her graduate students, as well as other lab groups, to build similar and even better spaces in the future.

When answers to practical questions such as these are approached deliberately, the result can be powerful and long-lasting. “Lab meetings can be some of the most memorable and rewarding moments in our academic careers,” write the authors, and can help “increase diversity in science, boost scientific creativity, and facilitate problem solving.”

Perhaps most powerfully, the paper’s authors argue that what happens in the lab doesn’t just stay in the lab — it ripples out into society at large. “Science isn’t isolated from what’s happening outside of academia,” says Nigel Golden, co-lead author, graduate student in environmental conservation, and a fellow at the Northeast Climate Adaptation Science Center, “the world is influencing our science, and our science is influencing the rest of the world.”

Devarajan, Morelli and Golden have also all been recognized as leaders in the effort to diversify science. Devarajan is a recipient of the organismic and evolutionary biology program’s Justice, Equity, Diversity, and Inclusion Fellowship, Morelli has received the department of environmental conservation’s Diversity, Equity, and Inclusion award, and Golden is a recipient of the College of Natural Science’s award for outstanding achievement in inclusion and excellence.

We wish to say thanks to the writer of this short article for this awesome web content

How more inclusive lab meetings lead to better science

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Journal Reference:

  1. Nigel Golden, Kadambari Devarajan, Cathleen Balantic, Joseph Drake, Michael T. Hallworth, Toni Lyn Morelli. Ten simple rules for productive lab meetings. PLOS Computational Biology, 2021; 17 (5): e1008953 DOI: 10.1371/journal.pcbi.1008953

The word “scientist” might conjure images of lab-coated researchers tending bubbling beakers or building supercomputers, but an enormous amount of scientific work takes place around a conference table during weekly group meetings. “There is plenty of good research showing that diversity and inclusion make the science itself better,” says Kadambari Devarajan, one of the paper’s co-lead authors and a graduate student in organismic and evolutionary biology as well as environmental conservation. Such diversity and inclusion starts with the structure of the lab meeting itself. Kadambari and her colleagues developed a set of ten guiding principles that help to cultivate lab environments that are inclusive as well productive lab environment, which range from the practical — “Rule 2: Identify roles and rules” and “Rule 6: Manage conflict” — to the interpersonal: “Rule 5: Be respectful and practice civility” and “Rule 9: Be aware of biases.”

Each of the ten rules came out of the team’s own working practice, honed by years of use, in Toni Lyn Morelli’s lab, whose members hail from countries around the globe and are in various stages of their careers. Morelli (Northeast Climate Adaptation Science Center and US Geological Survey), a co-author of the paper and a research ecologist affiliated with the environmental conservation department as well as the organismic and evolutionary biology program, notes that though diversity and inclusion are of interest far beyond the realm of science, there’s not always a practical guide to go by. “How does one create a diverse and inclusive lab that enables all members to bring their whole selves? What week-to-week actions can reinforce the sense of community and increase an individual’s, and thus the whole group’s, productivity?” She hopes that these guidelines can act as inspiration for her graduate students, as well as other lab groups, to build similar and even better spaces in the future.

When answers to practical questions such as these are approached deliberately, the result can be powerful and long-lasting. “Lab meetings can be some of the most memorable and rewarding moments in our academic careers,” write the authors, and can help “increase diversity in science, boost scientific creativity, and facilitate problem solving.”

Perhaps most powerfully, the paper’s authors argue that what happens in the lab doesn’t just stay in the lab — it ripples out into society at large. “Science isn’t isolated from what’s happening outside of academia,” says Nigel Golden, co-lead author, graduate student in environmental conservation, and a fellow at the Northeast Climate Adaptation Science Center, “the world is influencing our science, and our science is influencing the rest of the world.”

Devarajan, Morelli and Golden have also all been recognized as leaders in the effort to diversify science. Devarajan is a recipient of the organismic and evolutionary biology program’s Justice, Equity, Diversity, and Inclusion Fellowship, Morelli has received the department of environmental conservation’s Diversity, Equity, and Inclusion award, and Golden is a recipient of the College of Natural Science’s award for outstanding achievement in inclusion and excellence.

We wish to say thanks to the writer of this short article for this awesome web content

How more inclusive lab meetings lead to better science

" ["date_timestamp"]=> int(1638731561) } [1]=> array(11) { ["title"]=> string(63) "The Kremlin offers itself VKontakte, the “Russian Facebook”" ["link"]=> string(87) "https://bofads.com/world-news/the-kremlin-offers-itself-vkontakte-the-russian-facebook/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 18:34:42 +0000" ["category"]=> string(47) "World NewsFacebookKremlinoffersRussianVKontakte" ["guid"]=> string(26) "https://bofads.com/?p=7829" ["description"]=> string(646) "Mobile phones on which the sites of VKontakte, Mail.ru and Yandex, the Russian search engine, are open, on May 17, 2017. GLEB GARANICH / REUTERS The Kremlin is increasing its hold on Russian social networks. After a series of transactions, Gazprom, through its subsidiaries, obtained more than 50% of the voting rights in VKontakte – ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4845) "

The Kremlin is increasing its hold on Russian social networks. After a series of transactions, Gazprom, through its subsidiaries, obtained more than 50% of the voting rights in VKontakte – the “Russian Facebook”, with more than 100 million users worldwide – making , de facto, of the social network a state enterprise.

On Thursday, December 2, Russian billionaire Alicher Ousmanov sold 45% of his shares in the MF Technologies group, the company that controls VKontakte, to the insurance company Sogaz, a subsidiary of the state-owned oil giant Gazprom. At the same time, Gazprombank, the financial arm of the energy giant, increased its stake in the group from 36% to 45%, before entrusting its shares on Friday to Gazprom-Media, the media and communication branch of the parent company. The transaction does not have a great economic value, as the two Gazprom companies will receive less than 5% of the profits. It is above all a matter of making it a tool of influence. Gazprom-Media already owns 38 televisions and 10 radio stations.

Read also Article reserved for our subscribers Russia in search of “sovereignty” on the Internet

VKontakte restera “An independent company”, Gazprom-Media assured Friday, without convincing. Very popular in Russian speaking countries, VKontakte was established in 2006 by Pavel Durov, also designer of Telegram protected messaging. This social network has always tried to escape the hands of power. In vain.

Infiltrated by the FSB

Already in 2011, VKontakte had to publish in the press an open letter entitled “VKontakte will remain independent” to reassure its users, after the arrival of new shareholders who were not the type to oppose the Kremlin’s requests. A year later, the intelligence services had asked the site to block the accounts of the opponent Alexeï Navalny. At the time, the network was the main place of expression of the opposition and of organizing rallies.

As guarantor of the independence of his company, Pavel Dourov refused to give in to the injunctions of the FSB, which never let go. In 2013, the services asked him for access to the accounts of Ukrainian activists engaged in the pro-European demonstrations in Maidan Square in Kiev. Mr Durov then left the country in 2014, never to return. He acquired French nationality in August.

Read also Article reserved for our subscribers In Central Asia, Facebook and YouTube adjust to political censorship

Since the departure of its creator, VKontakte has kept the reputation of a completely infiltrated social network by the FSB. Despite the departure of some of the users to Facebook and a blocking of the application (bypassed en masse) in Ukraine, the social network has not lost any of its power. More than half of the Russian population is said to be registered there.

You have 39.15% of this article left to read. The rest is for subscribers only.

We would love to say thanks to the author of this post for this incredible web content

The Kremlin offers itself VKontakte, the “Russian Facebook”

" } ["summary"]=> string(646) "Mobile phones on which the sites of VKontakte, Mail.ru and Yandex, the Russian search engine, are open, on May 17, 2017. GLEB GARANICH / REUTERS The Kremlin is increasing its hold on Russian social networks. After a series of transactions, Gazprom, through its subsidiaries, obtained more than 50% of the voting rights in VKontakte – ... Read more" ["atom_content"]=> string(4845) "

The Kremlin is increasing its hold on Russian social networks. After a series of transactions, Gazprom, through its subsidiaries, obtained more than 50% of the voting rights in VKontakte – the “Russian Facebook”, with more than 100 million users worldwide – making , de facto, of the social network a state enterprise.

On Thursday, December 2, Russian billionaire Alicher Ousmanov sold 45% of his shares in the MF Technologies group, the company that controls VKontakte, to the insurance company Sogaz, a subsidiary of the state-owned oil giant Gazprom. At the same time, Gazprombank, the financial arm of the energy giant, increased its stake in the group from 36% to 45%, before entrusting its shares on Friday to Gazprom-Media, the media and communication branch of the parent company. The transaction does not have a great economic value, as the two Gazprom companies will receive less than 5% of the profits. It is above all a matter of making it a tool of influence. Gazprom-Media already owns 38 televisions and 10 radio stations.

Read also Article reserved for our subscribers Russia in search of “sovereignty” on the Internet

VKontakte restera “An independent company”, Gazprom-Media assured Friday, without convincing. Very popular in Russian speaking countries, VKontakte was established in 2006 by Pavel Durov, also designer of Telegram protected messaging. This social network has always tried to escape the hands of power. In vain.

Infiltrated by the FSB

Already in 2011, VKontakte had to publish in the press an open letter entitled “VKontakte will remain independent” to reassure its users, after the arrival of new shareholders who were not the type to oppose the Kremlin’s requests. A year later, the intelligence services had asked the site to block the accounts of the opponent Alexeï Navalny. At the time, the network was the main place of expression of the opposition and of organizing rallies.

As guarantor of the independence of his company, Pavel Dourov refused to give in to the injunctions of the FSB, which never let go. In 2013, the services asked him for access to the accounts of Ukrainian activists engaged in the pro-European demonstrations in Maidan Square in Kiev. Mr Durov then left the country in 2014, never to return. He acquired French nationality in August.

Read also Article reserved for our subscribers In Central Asia, Facebook and YouTube adjust to political censorship

Since the departure of its creator, VKontakte has kept the reputation of a completely infiltrated social network by the FSB. Despite the departure of some of the users to Facebook and a blocking of the application (bypassed en masse) in Ukraine, the social network has not lost any of its power. More than half of the Russian population is said to be registered there.

You have 39.15% of this article left to read. The rest is for subscribers only.

We would love to say thanks to the author of this post for this incredible web content

The Kremlin offers itself VKontakte, the “Russian Facebook”

" ["date_timestamp"]=> int(1638729282) } [2]=> array(11) { ["title"]=> string(81) "Juric: “Turin, you have to melt. Anxiety? We don’t have to give a damn …”" ["link"]=> string(90) "https://bofads.com/sport/juric-turin-you-have-to-melt-anxiety-we-dont-have-to-give-a-damn/" ["dc"]=> array(1) { ["creator"]=> string(8) "Tim Hall" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 18:06:26 +0000" ["category"]=> string(30) "SportAnxietydamnJuricmeltTurin" ["guid"]=> string(26) "https://bofads.com/?p=7826" ["description"]=> string(660) "The grenade technician loads the team ahead of the match against Cagliari in the conference. And it does it in its own way The first commandment, Ivan Juric, repeats it over and over again during a long conference on the eve: “We must free our heads, we must melt, without going out of our minds. ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5408) "

The grenade technician loads the team ahead of the match against Cagliari in the conference. And it does it in its own way

The first commandment, Ivan Juric, repeats it over and over again during a long conference on the eve: “We must free our heads, we must melt, without going out of our minds. I don’t want negativity or anxiety to enter the locker room right now, or for anyone to get nervous, after having slaughtered Roma and lost, and after playing a great match with Empoli, bringing home only one point “. He often dances between the politically correct, “we are a good team, I’m very happy: we’re doing great”, and a more candid language that is undoubtedly much more part of him, “we don’t have to give a shit …, now I want to talk with more sincerity, which I like even more: we must always attack with more men, score more and more goals and score many more points “. Juric is well loaded: after lunch he will direct the finishing process, in the afternoon there will be the departure for Cagliari where tomorrow he plans a blitz.

GROWTH

Certainly, he does not trust this Cagliari despite being penultimate in the standings. “Cagliari’s position is inexplicable looking at the level of the players they have. They have not lost in three games, they have become very tough – continues Juric -, it will certainly be a very tough match “. There is also the question of growth that the grenade technician invokes, practically, with every answer: “We must continue to grow, in the game, in the points, believing more in ourselves. We have to eliminate our mistakes as much as possible: we are a good team, but we have to do better. We must not be satisfied: we are missing something in certain departments at the level of game development. But I blindly believe in work and I have a lot of faith in these players, all very young. I think this further leap in quality can be made. Starting with Pjaca, which has been my obsession for five years: if it’s the one from the other night, it starts to get interesting ”.

NEXT 4

When the discussion slips on the calendar, Juric builds a perspective: “This is a strange championship, in which apart from the first four all the others are really very close. Let’s say that the next four matches (Cagliari, Bologna, Verona and Inter until Christmas, ed) will be able to tell us what kind of championship we will play. If we get closer to the ones in front. But, in any case, what we are doing in terms of performance is beyond all my expectations ”.

SANABRIA YOU HAVE TO DO MORE

Then there is the discourse on individuals. Here we start from Tonny Sanabria: with Belotti injured, the weight of the attack rests heavily on his shoulders. So far only two goals in the league, the last with Genoa. He’s still dry away. Juric pampers him, but expects much more from him: “Sanabria needs to improve. He certainly has qualities that allow us to play well, he has great technique, but now he has to score more goals. It is normal for the results to pass through this aspect: he can do something more in the implementation phase, but overall he is doing a good job. He’s a right guy, okay, I pamper him as well. But I expect something more in terms of implementation… “. He says on Praet “he still has to find his condition again, he has ups and downs. You have to manage it well without overloading it. But with him, Brekalo and Pjaca we have qualities on the trocar “, then he underlines on Zaza that” without Belotti, he will have more chances. I hope he will exploit them “. The latest on Lukic and Bremer: “They are two of my pillars. Lukic has found his own dimension on the pitch since we bet on a specific position after he had often played in multiple positions. The same applies to Bremer. The two of them are the heart of the team and are doing very well ”. He closes on Izzo: “Right now, by technical choice, he is behind Zima”. Rodriguez will be called up and will leave for Cagliari. Ansaldi and Verdi no (recoveries still far away), Mandragora will stay at home but from Tuesday he will return to train with the group.

We would love to say thanks to the writer of this write-up for this outstanding material

Juric: “Turin, you have to melt. Anxiety? We don’t have to give a damn …”

" } ["summary"]=> string(660) "The grenade technician loads the team ahead of the match against Cagliari in the conference. And it does it in its own way The first commandment, Ivan Juric, repeats it over and over again during a long conference on the eve: “We must free our heads, we must melt, without going out of our minds. ... Read more" ["atom_content"]=> string(5408) "

The grenade technician loads the team ahead of the match against Cagliari in the conference. And it does it in its own way

The first commandment, Ivan Juric, repeats it over and over again during a long conference on the eve: “We must free our heads, we must melt, without going out of our minds. I don’t want negativity or anxiety to enter the locker room right now, or for anyone to get nervous, after having slaughtered Roma and lost, and after playing a great match with Empoli, bringing home only one point “. He often dances between the politically correct, “we are a good team, I’m very happy: we’re doing great”, and a more candid language that is undoubtedly much more part of him, “we don’t have to give a shit …, now I want to talk with more sincerity, which I like even more: we must always attack with more men, score more and more goals and score many more points “. Juric is well loaded: after lunch he will direct the finishing process, in the afternoon there will be the departure for Cagliari where tomorrow he plans a blitz.

GROWTH

Certainly, he does not trust this Cagliari despite being penultimate in the standings. “Cagliari’s position is inexplicable looking at the level of the players they have. They have not lost in three games, they have become very tough – continues Juric -, it will certainly be a very tough match “. There is also the question of growth that the grenade technician invokes, practically, with every answer: “We must continue to grow, in the game, in the points, believing more in ourselves. We have to eliminate our mistakes as much as possible: we are a good team, but we have to do better. We must not be satisfied: we are missing something in certain departments at the level of game development. But I blindly believe in work and I have a lot of faith in these players, all very young. I think this further leap in quality can be made. Starting with Pjaca, which has been my obsession for five years: if it’s the one from the other night, it starts to get interesting ”.

NEXT 4

When the discussion slips on the calendar, Juric builds a perspective: “This is a strange championship, in which apart from the first four all the others are really very close. Let’s say that the next four matches (Cagliari, Bologna, Verona and Inter until Christmas, ed) will be able to tell us what kind of championship we will play. If we get closer to the ones in front. But, in any case, what we are doing in terms of performance is beyond all my expectations ”.

SANABRIA YOU HAVE TO DO MORE

Then there is the discourse on individuals. Here we start from Tonny Sanabria: with Belotti injured, the weight of the attack rests heavily on his shoulders. So far only two goals in the league, the last with Genoa. He’s still dry away. Juric pampers him, but expects much more from him: “Sanabria needs to improve. He certainly has qualities that allow us to play well, he has great technique, but now he has to score more goals. It is normal for the results to pass through this aspect: he can do something more in the implementation phase, but overall he is doing a good job. He’s a right guy, okay, I pamper him as well. But I expect something more in terms of implementation… “. He says on Praet “he still has to find his condition again, he has ups and downs. You have to manage it well without overloading it. But with him, Brekalo and Pjaca we have qualities on the trocar “, then he underlines on Zaza that” without Belotti, he will have more chances. I hope he will exploit them “. The latest on Lukic and Bremer: “They are two of my pillars. Lukic has found his own dimension on the pitch since we bet on a specific position after he had often played in multiple positions. The same applies to Bremer. The two of them are the heart of the team and are doing very well ”. He closes on Izzo: “Right now, by technical choice, he is behind Zima”. Rodriguez will be called up and will leave for Cagliari. Ansaldi and Verdi no (recoveries still far away), Mandragora will stay at home but from Tuesday he will return to train with the group.

We would love to say thanks to the writer of this write-up for this outstanding material

Juric: “Turin, you have to melt. Anxiety? We don’t have to give a damn …”

" ["date_timestamp"]=> int(1638727586) } [3]=> array(11) { ["title"]=> string(73) "Physicists exploit space and time symmetries to control quantum materials" ["link"]=> string(110) "https://bofads.com/healthandscience/physicists-exploit-space-and-time-symmetries-to-control-quantum-materials/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 17:55:21 +0000" ["category"]=> string(77) "Health And SciencecontrolexploitmaterialsPhysicistsquantumspacesymmetriestime" ["guid"]=> string(26) "https://bofads.com/?p=7824" ["description"]=> string(760) "Journal Reference: Charles Andrew Downing, Vasil Arkadievich Saroka. Exceptional points in oligomer chains. Communications Physics, 2021; 4 (1) DOI: 10.1038/s42005-021-00757-3 Two theoretical physicists, from the University of Exeter (United Kingdom) and the Norwegian University of Science and Technology (in Trondheim, Norway), have built a quantum theory describing a chain of quantum resonators satisfying space reflection ... Read more" ["content"]=> array(1) { ["encoded"]=> string(3622) "

Journal Reference:

  1. Charles Andrew Downing, Vasil Arkadievich Saroka. Exceptional points in oligomer chains. Communications Physics, 2021; 4 (1) DOI: 10.1038/s42005-021-00757-3

Two theoretical physicists, from the University of Exeter (United Kingdom) and the Norwegian University of Science and Technology (in Trondheim, Norway), have built a quantum theory describing a chain of quantum resonators satisfying space reflection and time reversal symmetries. They have shown how the different quantum phases of such chains are associated with remarkable phenomena, which may be useful in the design of future quantum devices relying on strong correlations.

A common distinction in physics is between open and closed systems. Closed systems are isolated from any external environment, such that energy is conserved because there is nowhere for it to escape to. Open systems are connected to the outer world, and via exchanges with the environment they are subject to energy gains and energy losses. There is an important third case. When the energy flowing in and flowing out of the system is finely balanced, an intermediate situation between being open and closed arises. This equilibrium can occur when the system obeys a combined symmetry of space and time, that is when (1) switching left and right and (2) flipping the arrow of time leave the system essentially unchanged.

In their latest research, Downing and Saroka discuss the phases of a quantum chain of resonators satisfying space reflection and time reversal symmetries. There are principally two phases of interest, a trivial phase (accompanied by intuitive physics) and a nontrivial phase (marked with surprising physics). The border between these two phases is marked by an exceptional point. The researchers have found the locations of these exceptional points for a chain with an arbitrary number of resonators, providing insight into the scaling up of quantum systems obeying these symmetries. Importantly, the nontrivial phase allows for unconventional transport effects and strong quantum correlations, which may be used to control the behaviour and propagation of light at nanoscopic length scales.

This theoretical study may be useful for the generation, manipulation and control of light in low-dimensional quantum materials, with a view to building light-based devices exploiting photons, the particles of light, as workhorses down at sizes around one billionth of a meter.

Charles Downing, from the University of Exeter, commented: “Our work on parity-time symmetry in open quantum systems further emphasises how symmetry underpins our understanding of the physical world, and how we may benefit from it.”

Vasil Saroka, from the Norwegian University of Science and Technology, added: “We hope that our theoretical work on parity-time symmetry can inspire further experimental research in this exciting area of physics.”

We want to say thanks to the writer of this short article for this amazing content

Physicists exploit space and time symmetries to control quantum materials

" } ["summary"]=> string(760) "Journal Reference: Charles Andrew Downing, Vasil Arkadievich Saroka. Exceptional points in oligomer chains. Communications Physics, 2021; 4 (1) DOI: 10.1038/s42005-021-00757-3 Two theoretical physicists, from the University of Exeter (United Kingdom) and the Norwegian University of Science and Technology (in Trondheim, Norway), have built a quantum theory describing a chain of quantum resonators satisfying space reflection ... Read more" ["atom_content"]=> string(3622) "

Journal Reference:

  1. Charles Andrew Downing, Vasil Arkadievich Saroka. Exceptional points in oligomer chains. Communications Physics, 2021; 4 (1) DOI: 10.1038/s42005-021-00757-3

Two theoretical physicists, from the University of Exeter (United Kingdom) and the Norwegian University of Science and Technology (in Trondheim, Norway), have built a quantum theory describing a chain of quantum resonators satisfying space reflection and time reversal symmetries. They have shown how the different quantum phases of such chains are associated with remarkable phenomena, which may be useful in the design of future quantum devices relying on strong correlations.

A common distinction in physics is between open and closed systems. Closed systems are isolated from any external environment, such that energy is conserved because there is nowhere for it to escape to. Open systems are connected to the outer world, and via exchanges with the environment they are subject to energy gains and energy losses. There is an important third case. When the energy flowing in and flowing out of the system is finely balanced, an intermediate situation between being open and closed arises. This equilibrium can occur when the system obeys a combined symmetry of space and time, that is when (1) switching left and right and (2) flipping the arrow of time leave the system essentially unchanged.

In their latest research, Downing and Saroka discuss the phases of a quantum chain of resonators satisfying space reflection and time reversal symmetries. There are principally two phases of interest, a trivial phase (accompanied by intuitive physics) and a nontrivial phase (marked with surprising physics). The border between these two phases is marked by an exceptional point. The researchers have found the locations of these exceptional points for a chain with an arbitrary number of resonators, providing insight into the scaling up of quantum systems obeying these symmetries. Importantly, the nontrivial phase allows for unconventional transport effects and strong quantum correlations, which may be used to control the behaviour and propagation of light at nanoscopic length scales.

This theoretical study may be useful for the generation, manipulation and control of light in low-dimensional quantum materials, with a view to building light-based devices exploiting photons, the particles of light, as workhorses down at sizes around one billionth of a meter.

Charles Downing, from the University of Exeter, commented: “Our work on parity-time symmetry in open quantum systems further emphasises how symmetry underpins our understanding of the physical world, and how we may benefit from it.”

Vasil Saroka, from the Norwegian University of Science and Technology, added: “We hope that our theoretical work on parity-time symmetry can inspire further experimental research in this exciting area of physics.”

We want to say thanks to the writer of this short article for this amazing content

Physicists exploit space and time symmetries to control quantum materials

" ["date_timestamp"]=> int(1638726921) } [4]=> array(11) { ["title"]=> string(93) "X Factor 2021: in the final the talents duet with their judge. Coldplay and Måneskin guests" ["link"]=> string(115) "https://bofads.com/music/x-factor-2021-in-the-final-the-talents-duet-with-their-judge-coldplay-and-maneskin-guests/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 17:34:35 +0000" ["category"]=> string(55) "MusicColdplayduetFactorFinalguestsjudgeMåneskintalents" ["guid"]=> string(26) "https://bofads.com/?p=7821" ["description"]=> string(678) "X Factor 2021 final coming up … Thursday 9 December at 21.15 on Sky One (channel 108, digital terrestrial channel 455) and in simulcast on TV8 (at button 8 on the remote control) we could witness the final act of the show from the Assago Forum of. Milan. In this edition each judge brings with ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6508) "

X Factor 2021 final coming up … Thursday 9 December at 21.15 on Sky One (channel 108, digital terrestrial channel 455) and in simulcast on TV8 (at button 8 on the remote control) we could witness the final act of the show from the Assago Forum of. Milan.

In this edition each judge brings with him a competitor: Baltimore in the roster of Hell Raton, gIANMARIA in the roster of Emma, i Bengala Fire with Manuel Agnelli e Fellow with Mika.

The two guests of the grand finale are from Coldplay, name revealed already in the first episode of the live shows and, announced in the semifinal, i Moonlight who return to the stage where they have found success as artists who have conquered Italy, Europe and the USA.

X FActor 2021 final: the round

The evening will be divided into 3 rounds, and at the end of each of them the competitor least voted by the public will have to abandon the race.

The first heat will develop with the Duets, and will see the four finalists as protagonists, each one flanked by their own judge.

The second will be the Best Of, in which the three remaining artists will be able to perform with a medley of the songs they have presented during these weeks.

Last round dedicated to the warhorses of the two singers still in the game, and among these the public will choose the winner of X Factor 2021.

WE KNOW THE FINALISTS BETTER

Baltimore

To the registry office Edoardo Spinsante, is a very young and slightly nerdy student, with a very interesting voice and pen. He plays the piano, the guitar and also gets his hands on the production.

He immediately made it clear that he focused heavily on texts and on the strength of the word: in the selections he proposed two of his pieces e The fashion ballad from Luigi Tenco. During the Live Shows he brought songs by Carmen Consoli, Adele, Lucio Battisti e Morgan.

His original songs presented during the episodes were Other and the namesake Baltimore. In the semifinal he duet with Lightning.

Bengala Fire

I am Davide Bortoletto (Borto), Mattia Mariuzzo (Mario), Andrea Orsella (Bear), Alexander Puntel (The former). They form a group with a strong Brit-rock appeal in which each of the 4 has their own musical influences: they have been playing together for about 11 years, they have known each other since they were little and to unite them there is above all the boundless love for rock’n ‘ roll.

After having presented your piece at the Auditions Valencia (re-performed during the Live Shows, together with the other song My bitter), they proposed to Bootcamps Television Mind of the DC fountains also winning the compliments from the Irish band. Over the course of these weeks, they have brought – among others – covers of Interpol, Blur, The Kinks, The Fratellis, For the semifinal they duet with Receive.

Fellow

20 years old, from Turin, Federico Castello in art Fellow is a waiter and songwriter with a soulful voice and very curly hair. He writes in both Italian and English, plays the piano, is a classic but up-to-date singer. He presented himself at the selections describing himself as a big fan of Mika, who then wanted him on his roster.

During the Live Show he proposed his original songs Fire e Don’t make me go, as well as covers – among others – of Harry Styles, Elisa, Coldplay, Florence + The Machine e Benjamin Clementine, the latter one of his reference songwriters, with whom he was also able to duet during the semifinal.

gIANMARIA

In the registry office Gianmaria Volpatom seems to be the portrait of his generation: with a well-groomed appearance and solid thoughts, he often appears elusive and introverted. He has a fairly complex worldview which is reflected in his music and lyrics.

He has been noticed since the selections especially with his two songs presented at the Auditions and Bootcamps, respectively The suicides e Sorry mom; during the Live Show he was the protagonist of an intense journey into the great Italian songwriter, bringing covers of CCCP, Vasco Rossi, Francesco De Gregori, Lucio Dalla, Milva. During the episodes dedicated to the original songs, he brought his own The suicides e Without saliva, while in the semifinals he sang with Samuel Bersani.

We would love to say thanks to the author of this write-up for this incredible material

X Factor 2021: in the final the talents duet with their judge. Coldplay and Måneskin guests

" } ["summary"]=> string(678) "X Factor 2021 final coming up … Thursday 9 December at 21.15 on Sky One (channel 108, digital terrestrial channel 455) and in simulcast on TV8 (at button 8 on the remote control) we could witness the final act of the show from the Assago Forum of. Milan. In this edition each judge brings with ... Read more" ["atom_content"]=> string(6508) "

X Factor 2021 final coming up … Thursday 9 December at 21.15 on Sky One (channel 108, digital terrestrial channel 455) and in simulcast on TV8 (at button 8 on the remote control) we could witness the final act of the show from the Assago Forum of. Milan.

In this edition each judge brings with him a competitor: Baltimore in the roster of Hell Raton, gIANMARIA in the roster of Emma, i Bengala Fire with Manuel Agnelli e Fellow with Mika.

The two guests of the grand finale are from Coldplay, name revealed already in the first episode of the live shows and, announced in the semifinal, i Moonlight who return to the stage where they have found success as artists who have conquered Italy, Europe and the USA.

X FActor 2021 final: the round

The evening will be divided into 3 rounds, and at the end of each of them the competitor least voted by the public will have to abandon the race.

The first heat will develop with the Duets, and will see the four finalists as protagonists, each one flanked by their own judge.

The second will be the Best Of, in which the three remaining artists will be able to perform with a medley of the songs they have presented during these weeks.

Last round dedicated to the warhorses of the two singers still in the game, and among these the public will choose the winner of X Factor 2021.

WE KNOW THE FINALISTS BETTER

Baltimore

To the registry office Edoardo Spinsante, is a very young and slightly nerdy student, with a very interesting voice and pen. He plays the piano, the guitar and also gets his hands on the production.

He immediately made it clear that he focused heavily on texts and on the strength of the word: in the selections he proposed two of his pieces e The fashion ballad from Luigi Tenco. During the Live Shows he brought songs by Carmen Consoli, Adele, Lucio Battisti e Morgan.

His original songs presented during the episodes were Other and the namesake Baltimore. In the semifinal he duet with Lightning.

Bengala Fire

I am Davide Bortoletto (Borto), Mattia Mariuzzo (Mario), Andrea Orsella (Bear), Alexander Puntel (The former). They form a group with a strong Brit-rock appeal in which each of the 4 has their own musical influences: they have been playing together for about 11 years, they have known each other since they were little and to unite them there is above all the boundless love for rock’n ‘ roll.

After having presented your piece at the Auditions Valencia (re-performed during the Live Shows, together with the other song My bitter), they proposed to Bootcamps Television Mind of the DC fountains also winning the compliments from the Irish band. Over the course of these weeks, they have brought – among others – covers of Interpol, Blur, The Kinks, The Fratellis, For the semifinal they duet with Receive.

Fellow

20 years old, from Turin, Federico Castello in art Fellow is a waiter and songwriter with a soulful voice and very curly hair. He writes in both Italian and English, plays the piano, is a classic but up-to-date singer. He presented himself at the selections describing himself as a big fan of Mika, who then wanted him on his roster.

During the Live Show he proposed his original songs Fire e Don’t make me go, as well as covers – among others – of Harry Styles, Elisa, Coldplay, Florence + The Machine e Benjamin Clementine, the latter one of his reference songwriters, with whom he was also able to duet during the semifinal.

gIANMARIA

In the registry office Gianmaria Volpatom seems to be the portrait of his generation: with a well-groomed appearance and solid thoughts, he often appears elusive and introverted. He has a fairly complex worldview which is reflected in his music and lyrics.

He has been noticed since the selections especially with his two songs presented at the Auditions and Bootcamps, respectively The suicides e Sorry mom; during the Live Show he was the protagonist of an intense journey into the great Italian songwriter, bringing covers of CCCP, Vasco Rossi, Francesco De Gregori, Lucio Dalla, Milva. During the episodes dedicated to the original songs, he brought his own The suicides e Without saliva, while in the semifinals he sang with Samuel Bersani.

We would love to say thanks to the author of this write-up for this incredible material

X Factor 2021: in the final the talents duet with their judge. Coldplay and Måneskin guests

" ["date_timestamp"]=> int(1638725675) } [5]=> array(11) { ["title"]=> string(62) "Ruth Gbagbi, the taekwondo champion who inspires Ivorian youth" ["link"]=> string(92) "https://bofads.com/world-news/ruth-gbagbi-the-taekwondo-champion-who-inspires-ivorian-youth/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 17:10:31 +0000" ["category"]=> string(57) "World NewschampionGbagbiinspiresIvorianRuthtaekwondoyouth" ["guid"]=> string(26) "https://bofads.com/?p=7818" ["description"]=> string(614) "To not miss anything on African news, subscribe to the newsletter of World Africa from this link. Every Saturday at 6 a.m., find a week of current events and debates treated by the editorial staff of World Africa. During the Tokyo Olympics, Ivorian Ruth Gbagbi faces Brazilian Milena Titoneli in the under 67 kg category ... Read more" ["content"]=> array(1) { ["encoded"]=> string(8768) "

To not miss anything on African news, subscribe to the newsletter of World Africa from this link. Every Saturday at 6 a.m., find a week of current events and debates treated by the editorial staff of World Africa.

During the Tokyo Olympics, Ivorian Ruth Gbagbi faces Brazilian Milena Titoneli in the under 67 kg category on July 16, 2021.

Ruth Gbagbi is not the type to boast. But this Tuesday, November 30, at the Taekwondo Palace in Abidjan, the Ivorian athlete willingly takes a few dance steps to the sound of songs and maracas from the handful of Ivorian supporters who have come to welcome him. “Champion, have a good arrival oooh, champion a safe arrival oooh! “, they proclaim in chorus. National flag on the back and gold medal around the neck, she celebrates with them her second title of world champion obtained on November 27 in Riyadh, Saudi Arabia.

Read also Tokyo 2021 Olympics: Africa wins 37 medals but does less well than in Rio

The taekwondo, now number two in the world ranking under 67 kg, won in the final against the French Magda Wiet-Hénin (11-5), European champion 2020 in Sarajevo. “I fought with my experience, my calm, my techniques, I worked on the strategy to win”, she analyzes, happy but tired after these championships organized in the Saudi dampness.

This medal gleaned during the first world taekwondo championships exclusively for women adds to the beautiful collection of the 27-year-old Ivorian star. Five-time African champion, double world champion therefore and double bronze medalist at the Olympic Games, she is today one of the most successful sportswomen in the country, behind several disabled athletes including the unbeatable runner Oumar Koné and her 83 medals.

Iron discipline

This concludes a very good year for Ruth Gbagbi, also bronze medalist at the Tokyo Games this summer, a performance that she considers “Satisfactory” despite the announced hopes of Olympic gold. His trainer Adama Chérif is harder: “We stumbled in Tokyo, we had to start again, luckily there was this competition just after. “

The season had started in earnest in June with the national team in the mountains of western Ivory Coast. An unprecedented physical preparation at an altitude of almost 1,000 meters, far from the tatami mats of its training center in Mallorca, Spain. And the Ivorian air seems to please her since she had already returned to her land to prepare for the 2019 season after a serious forearm injury. At the time, it also paid off: she had become world number one a few months later.

Thanks to his preparation and an iron discipline, his track record grows and his determination is only strengthened. “I know I can do even better, she believes. Winning an Olympic gold medal, winning even more world titles, grand prizes, being first everywhere in fact. “

Read also In Côte d’Ivoire, taekwondo has become the second national sport after football

As on the carpets where she impresses with her speed and ability to move, Ruth Gbagbi is constantly moving forward. “If you stay to glorify yourself after a victory, be sure that you will not move forward, launches as a maxim Adama Chérif. It is thanks to this character that she is constant, she opens a new page each time. “

This state of mind is the fruit of the teaching and values ​​of South Korean sport, exported to Côte d’Ivoire in the 1960s when master Kim Young Tae came to train Ivorian masters. “Asia and Africa have a common character, compares Adama Chérif. In these cultures, we rely on respect for elders. And this is Ruth’s strength: she is very attentive, she has confidence in herself and she works. “

A radically different temperament from the more rebellious one she had as a child in the streets of her Koumassi neighborhood in Abidjan. “When I was little, I missed school, I hung out in the neighborhood, I liked playing video games and I fought a lot. When I was 9, my mother told me that she was going to register me for taekwondo so that I could be hit., she laughs again. Now it’s the opposite, I’m a champion and she’s proud of me. “

Second sport in the country

The martial art gave him discipline and a way to channel himself: “Now I can manage my emotions. As soon as I arrived in the national team, it was the routine: ‘training, studies, rest, training, studies, rest. It framed me and allowed me to be who I am today. “

The one who started very young with football has the same idol as the vast majority of Ivorians: the international Didier Drogba, with whom she sometimes exchanges. In turn, she begins to make a name for herself. “People recognize me more than before, they give me a little more importance”, she feels. These days, we can even see his face in the streets of Abidjan, plastered on buses and billboards. “She is a model, she is very ambitious, optimistic, humble, she goes for it, Côte d’Ivoire is proud of her”, launches Denise, member of the animation committee of Ivorian athletes.

Also read: Rio 2016 Olympics: gold medalist Cheick Cissé makes the Ivory Coast love taekwondo

Proud of her country and active on social networks, she is widely followed by Ivorian youth, who today rush to taekwondo clubs across the country to follow in her footsteps. In Côte d’Ivoire, the number of licensees continues to grow: from 16,000 to over 46,000 in ten years, making martial art the second sport in the country after football.

His success as well as that of Cheick Cissé, Olympic champion in 2016 in Rio, have a lot to do with it. And if Ruth Gbagbi has not finished winning titles, she is already preparing the next generation: “I have to share my experience with the youngest so that they can exceed the level I have today”, hopes the champion. Humble in all circumstances.

We wish to thank the author of this write-up for this outstanding content

Ruth Gbagbi, the taekwondo champion who inspires Ivorian youth

" } ["summary"]=> string(614) "To not miss anything on African news, subscribe to the newsletter of World Africa from this link. Every Saturday at 6 a.m., find a week of current events and debates treated by the editorial staff of World Africa. During the Tokyo Olympics, Ivorian Ruth Gbagbi faces Brazilian Milena Titoneli in the under 67 kg category ... Read more" ["atom_content"]=> string(8768) "

To not miss anything on African news, subscribe to the newsletter of World Africa from this link. Every Saturday at 6 a.m., find a week of current events and debates treated by the editorial staff of World Africa.

During the Tokyo Olympics, Ivorian Ruth Gbagbi faces Brazilian Milena Titoneli in the under 67 kg category on July 16, 2021.

Ruth Gbagbi is not the type to boast. But this Tuesday, November 30, at the Taekwondo Palace in Abidjan, the Ivorian athlete willingly takes a few dance steps to the sound of songs and maracas from the handful of Ivorian supporters who have come to welcome him. “Champion, have a good arrival oooh, champion a safe arrival oooh! “, they proclaim in chorus. National flag on the back and gold medal around the neck, she celebrates with them her second title of world champion obtained on November 27 in Riyadh, Saudi Arabia.

Read also Tokyo 2021 Olympics: Africa wins 37 medals but does less well than in Rio

The taekwondo, now number two in the world ranking under 67 kg, won in the final against the French Magda Wiet-Hénin (11-5), European champion 2020 in Sarajevo. “I fought with my experience, my calm, my techniques, I worked on the strategy to win”, she analyzes, happy but tired after these championships organized in the Saudi dampness.

This medal gleaned during the first world taekwondo championships exclusively for women adds to the beautiful collection of the 27-year-old Ivorian star. Five-time African champion, double world champion therefore and double bronze medalist at the Olympic Games, she is today one of the most successful sportswomen in the country, behind several disabled athletes including the unbeatable runner Oumar Koné and her 83 medals.

Iron discipline

This concludes a very good year for Ruth Gbagbi, also bronze medalist at the Tokyo Games this summer, a performance that she considers “Satisfactory” despite the announced hopes of Olympic gold. His trainer Adama Chérif is harder: “We stumbled in Tokyo, we had to start again, luckily there was this competition just after. “

The season had started in earnest in June with the national team in the mountains of western Ivory Coast. An unprecedented physical preparation at an altitude of almost 1,000 meters, far from the tatami mats of its training center in Mallorca, Spain. And the Ivorian air seems to please her since she had already returned to her land to prepare for the 2019 season after a serious forearm injury. At the time, it also paid off: she had become world number one a few months later.

Thanks to his preparation and an iron discipline, his track record grows and his determination is only strengthened. “I know I can do even better, she believes. Winning an Olympic gold medal, winning even more world titles, grand prizes, being first everywhere in fact. “

Read also In Côte d’Ivoire, taekwondo has become the second national sport after football

As on the carpets where she impresses with her speed and ability to move, Ruth Gbagbi is constantly moving forward. “If you stay to glorify yourself after a victory, be sure that you will not move forward, launches as a maxim Adama Chérif. It is thanks to this character that she is constant, she opens a new page each time. “

This state of mind is the fruit of the teaching and values ​​of South Korean sport, exported to Côte d’Ivoire in the 1960s when master Kim Young Tae came to train Ivorian masters. “Asia and Africa have a common character, compares Adama Chérif. In these cultures, we rely on respect for elders. And this is Ruth’s strength: she is very attentive, she has confidence in herself and she works. “

A radically different temperament from the more rebellious one she had as a child in the streets of her Koumassi neighborhood in Abidjan. “When I was little, I missed school, I hung out in the neighborhood, I liked playing video games and I fought a lot. When I was 9, my mother told me that she was going to register me for taekwondo so that I could be hit., she laughs again. Now it’s the opposite, I’m a champion and she’s proud of me. “

Second sport in the country

The martial art gave him discipline and a way to channel himself: “Now I can manage my emotions. As soon as I arrived in the national team, it was the routine: ‘training, studies, rest, training, studies, rest. It framed me and allowed me to be who I am today. “

The one who started very young with football has the same idol as the vast majority of Ivorians: the international Didier Drogba, with whom she sometimes exchanges. In turn, she begins to make a name for herself. “People recognize me more than before, they give me a little more importance”, she feels. These days, we can even see his face in the streets of Abidjan, plastered on buses and billboards. “She is a model, she is very ambitious, optimistic, humble, she goes for it, Côte d’Ivoire is proud of her”, launches Denise, member of the animation committee of Ivorian athletes.

Also read: Rio 2016 Olympics: gold medalist Cheick Cissé makes the Ivory Coast love taekwondo

Proud of her country and active on social networks, she is widely followed by Ivorian youth, who today rush to taekwondo clubs across the country to follow in her footsteps. In Côte d’Ivoire, the number of licensees continues to grow: from 16,000 to over 46,000 in ten years, making martial art the second sport in the country after football.

His success as well as that of Cheick Cissé, Olympic champion in 2016 in Rio, have a lot to do with it. And if Ruth Gbagbi has not finished winning titles, she is already preparing the next generation: “I have to share my experience with the youngest so that they can exceed the level I have today”, hopes the champion. Humble in all circumstances.

We wish to thank the author of this write-up for this outstanding content

Ruth Gbagbi, the taekwondo champion who inspires Ivorian youth

" ["date_timestamp"]=> int(1638724231) } [6]=> array(11) { ["title"]=> string(51) "Probiotics improve nausea and vomiting in pregnancy" ["link"]=> string(88) "https://bofads.com/healthandscience/probiotics-improve-nausea-and-vomiting-in-pregnancy/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 16:38:15 +0000" ["category"]=> string(58) "Health And ScienceimprovenauseapregnancyProbioticsvomiting" ["guid"]=> string(26) "https://bofads.com/?p=7816" ["description"]=> string(655) "Journal Reference: Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan. Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy. Nutrients, 2021; 13 (11): 3931 DOI: 10.3390/nu13113931 Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy. “The cause of ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6433) "

Journal Reference:

  1. Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan. Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy. Nutrients, 2021; 13 (11): 3931 DOI: 10.3390/nu13113931

Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy.

“The cause of nausea and vomiting during pregnancy is unknown to this date. Various theories have been proposed, but none of them is conclusive,” said Albert T. Liu, lead author for the study and a professor of obstetrics and gynecology.

“Nausea, vomiting and constipation during pregnancy can significantly diminish the quality of patients’ lives. Once nausea and vomiting during pregnancy progress, they can become difficult to control, and sometimes the patient even needs to be hospitalized,” Liu said.

Beneficial microbes

Probiotics are referred to as “beneficial bacteria.” They can be found in foods like yogurt, kimchi, kefir, sauerkraut and tempeh. Probiotics are also available as food supplements. According to the National Center for Complementary and Integrative Health, other than vitamins, probiotics or prebiotics were the third most commonly used dietary supplement for adults.

Probiotics are thought to support the community of different microbes, often referred to as the “gut microbiome,” found in the gastrointestinal tract.

During pregnancy, hormones like estrogen and progesterone increase, bringing about many physical changes. These increases can also change the gut microbiome, which likely affects the digestive system functions and causes unwanted symptoms like nausea, vomiting and constipation.

The researchers set out to determine whether supplementing with a probiotic could be beneficial for gastrointestinal function during pregnancy.

The study lasted for 16 days. A total of 32 participants took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.

The probiotics were available over-the-counter and mainly containedLactobacillus., a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.

Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.

What the researchers found was that taking the probiotic significantly reduced nausea and vomiting. Nausea hours (the number of hours participants felt nauseous) were reduced by 16%, and the number of times they vomited was reduced by 33%. Probiotic intake also significantly improved symptoms related to quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.

Probiotics were also found to reduce constipation significantly.

“Over the years, I’ve observed that probiotics can reduce nausea and vomiting and ease constipation. It’s very encouraging that the study proved this to be true,” said Liu. “Probiotics have also benefited many of my other patients who weren’t in the study,” said Liu.

New clues from gut microbes and byproducts

Participants also contributed fecal specimens before and during the study. The samples were analyzed to identify the type and number of microbes and the different byproducts of digestion.

This allowed the researchers to examine whether biomarkers in the fecal specimens corresponded with more severe nausea and assess how the probiotics affected participants who began the study with different baseline biomarkers.

One finding was that a low amount of bacteria that carry an enzyme named bile salt hydrolase, which generates bile acid to absorb nutrients, was associated with more pregnancy-related vomiting. Probiotics increase bile salt hydrolase-producing bacteria, which may explain why the supplements decreased levels of nausea and vomiting.

Another finding was that high levels of the gut microbes Akkermansia and A. muciniphila at the beginning of the study were associated with more vomiting. The probiotic significantly reduced the amount of those particular microbes and also reduced vomiting. This suggests Akkermansia and A. muciniphila may be reliable biomarkers that can predict vomiting in pregnancy.

Another finding was that vitamin E levels increased after taking probiotics. Higher levels of vitamin E were associated with low vomiting scores.

“This research provides key insights about the impact of gut microbes on gastrointestinal function during pregnancy. Our gut microbiota explains why we are what we eat, and why bacteria-generated metabolites and products have a huge impact on our health,” said Wan. “They affect the gastrointestinal tract as well as skin health and neurological function.”

Although the findings are intriguing, the researchers caution that due to the small sample size, further studies will be needed to confirm the effects of the probiotics.

“Our previous work showed the benefits of probiotics in preventing liver inflammation. The current study might be one of the first to show the benefits of probiotics in pregnancy,” said Wan. “It would be interesting and important to further test whether probiotics can reduce nausea and vomiting caused by chemotherapy in cancer patients.”

Additional authors on this study include Shuai Chen from the Department of Public Health Sciences, and Prasant Kumar Jena, Lili Sheng and Ying Hu from the Department of Pathology and Laboratory Medicine at the University of California, Davis.

We wish to say thanks to the author of this short article for this incredible material

Probiotics improve nausea and vomiting in pregnancy

" } ["summary"]=> string(655) "Journal Reference: Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan. Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy. Nutrients, 2021; 13 (11): 3931 DOI: 10.3390/nu13113931 Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy. “The cause of ... Read more" ["atom_content"]=> string(6433) "

Journal Reference:

  1. Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan. Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy. Nutrients, 2021; 13 (11): 3931 DOI: 10.3390/nu13113931

Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy.

“The cause of nausea and vomiting during pregnancy is unknown to this date. Various theories have been proposed, but none of them is conclusive,” said Albert T. Liu, lead author for the study and a professor of obstetrics and gynecology.

“Nausea, vomiting and constipation during pregnancy can significantly diminish the quality of patients’ lives. Once nausea and vomiting during pregnancy progress, they can become difficult to control, and sometimes the patient even needs to be hospitalized,” Liu said.

Beneficial microbes

Probiotics are referred to as “beneficial bacteria.” They can be found in foods like yogurt, kimchi, kefir, sauerkraut and tempeh. Probiotics are also available as food supplements. According to the National Center for Complementary and Integrative Health, other than vitamins, probiotics or prebiotics were the third most commonly used dietary supplement for adults.

Probiotics are thought to support the community of different microbes, often referred to as the “gut microbiome,” found in the gastrointestinal tract.

During pregnancy, hormones like estrogen and progesterone increase, bringing about many physical changes. These increases can also change the gut microbiome, which likely affects the digestive system functions and causes unwanted symptoms like nausea, vomiting and constipation.

The researchers set out to determine whether supplementing with a probiotic could be beneficial for gastrointestinal function during pregnancy.

The study lasted for 16 days. A total of 32 participants took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.

The probiotics were available over-the-counter and mainly containedLactobacillus., a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.

Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.

What the researchers found was that taking the probiotic significantly reduced nausea and vomiting. Nausea hours (the number of hours participants felt nauseous) were reduced by 16%, and the number of times they vomited was reduced by 33%. Probiotic intake also significantly improved symptoms related to quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.

Probiotics were also found to reduce constipation significantly.

“Over the years, I’ve observed that probiotics can reduce nausea and vomiting and ease constipation. It’s very encouraging that the study proved this to be true,” said Liu. “Probiotics have also benefited many of my other patients who weren’t in the study,” said Liu.

New clues from gut microbes and byproducts

Participants also contributed fecal specimens before and during the study. The samples were analyzed to identify the type and number of microbes and the different byproducts of digestion.

This allowed the researchers to examine whether biomarkers in the fecal specimens corresponded with more severe nausea and assess how the probiotics affected participants who began the study with different baseline biomarkers.

One finding was that a low amount of bacteria that carry an enzyme named bile salt hydrolase, which generates bile acid to absorb nutrients, was associated with more pregnancy-related vomiting. Probiotics increase bile salt hydrolase-producing bacteria, which may explain why the supplements decreased levels of nausea and vomiting.

Another finding was that high levels of the gut microbes Akkermansia and A. muciniphila at the beginning of the study were associated with more vomiting. The probiotic significantly reduced the amount of those particular microbes and also reduced vomiting. This suggests Akkermansia and A. muciniphila may be reliable biomarkers that can predict vomiting in pregnancy.

Another finding was that vitamin E levels increased after taking probiotics. Higher levels of vitamin E were associated with low vomiting scores.

“This research provides key insights about the impact of gut microbes on gastrointestinal function during pregnancy. Our gut microbiota explains why we are what we eat, and why bacteria-generated metabolites and products have a huge impact on our health,” said Wan. “They affect the gastrointestinal tract as well as skin health and neurological function.”

Although the findings are intriguing, the researchers caution that due to the small sample size, further studies will be needed to confirm the effects of the probiotics.

“Our previous work showed the benefits of probiotics in preventing liver inflammation. The current study might be one of the first to show the benefits of probiotics in pregnancy,” said Wan. “It would be interesting and important to further test whether probiotics can reduce nausea and vomiting caused by chemotherapy in cancer patients.”

Additional authors on this study include Shuai Chen from the Department of Public Health Sciences, and Prasant Kumar Jena, Lili Sheng and Ying Hu from the Department of Pathology and Laboratory Medicine at the University of California, Davis.

We wish to say thanks to the author of this short article for this incredible material

Probiotics improve nausea and vomiting in pregnancy

" ["date_timestamp"]=> int(1638722295) } [7]=> array(11) { ["title"]=> string(98) "Belgians abroad: Christian Benteke and Crystal Palace beaten, no winner between Mangala and Boyata" ["link"]=> string(122) "https://bofads.com/sport/belgians-abroad-christian-benteke-and-crystal-palace-beaten-no-winner-between-mangala-and-boyata/" ["dc"]=> array(1) { ["creator"]=> string(8) "Tim Hall" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 16:36:54 +0000" ["category"]=> string(67) "SportbeatenBelgiansBentekeBoyataChristianCrystalMangalaPalacewinner" ["guid"]=> string(26) "https://bofads.com/?p=7813" ["description"]=> string(733) "FRANCE: By winning 0-5 in Saint-Etienne on Sunday as part of the 17th day of Ligue 1, Rennes (without Doku) took second place (31 points) in the French championship 11 units from PSG. To take advantage of Marseille’s misstep against Brest, Bruno Génésio, who attended the match from the stands, aligned Martin Terrier and Gaëtan ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5611) "

FRANCE:

By winning 0-5 in Saint-Etienne on Sunday as part of the 17th day of Ligue 1, Rennes (without Doku) took second place (31 points) in the French championship 11 units from PSG. To take advantage of Marseille’s misstep against Brest, Bruno Génésio, who attended the match from the stands, aligned Martin Terrier and Gaëtan Laborde as an attacking duo. After wasting a great opportunity on a pass from Laborde (5th), Terrier scored twice (22nd, 28th). Rennes took even more distance thanks to an autogoal from Yvann Maçon (45th, 0-3). On the restart, Terrier (48th, 0-4) and reservist Chimuanya Ugochukwu (83rd, 0-5) stunned the Greens a little more, who remain bottom of the standings (12 points).

AS Monaco, with 15 minutes Eliot Matazo, won 4-0 against FC Metz on Sunday afternoon for the 17th day of Ligue 1. A success which places the Monegasques in 6th place with 26 points. On the bench at kick-off, Eliot Matazo returned to the game in the 75th minute while his teammates were already leading 3-0. Sofiane Diop opened the scoring very early in the game (2nd, 1-0), before Kevin Volland doubled the score on a penalty shortly before half-time (44th, 2-0). Portugal’s Gelson Martins scored the third goal in the 57th.

The inevitable Wissam Ben Yedder was in charge of giving the score its final pace by planting the last achievement of his own (87th, 4-0).

At the same time, Reims lost 1-2 on their lawn against Angers. Wout Faes played the entire game for the Rémois, while Thomas Foket gave up his place ten minutes from time.

With this setback, Reims stagnated in 14th place with 19 units.

ITALY:

In Italy, Bologna facing Fiorentina. Among the visited, Arthur Theate played the entire match on the left side of the three-way defense and was warned for a foul on Nico Gonzalez (50th). At the start of the meeting, the Bolognese waited in their camp even if the Florentine goalkeeper, Pietro Terracciano, had to focus on a center from Theate (13th). In the middle of the period, the Bolognese began to be more threatening but on a against Youssef Maleh punished them (33rd, 0-1). But with a volley from the left, Musa Barrow brought the equality (42nd, 1-1). On the resumption, Cristiano Biraghi, on free kick (52nd, 1-2) and Dusan Vlahovic, on penalty, (67th, 1-3) gave air to the Tuscans, who nevertheless accused the blow on a strike deviated from Aaron Hickey (83rd, 2-3). In the standings, Fiorentina climbs to 5th position (27 points) and Bologna is 8th (24 points).

NETHERLANDS:

In the Netherlands, Waalwijk and his Belgian colony won 2-1 against Nijmegen. Shawn Asewoye and Dario Van den Buijs played the whole match, Lennerd Daneels came out (71st), Sebbe Augustijns got on the game (46th) while Thierry Lutonda and Jens Teuckens, the reserve goalkeeper, remained on the bench. After 15 days, Waalwijk is 15th (15 points) and Nijmegen 11th (19 points).

ENGLAND:

Crystal Palace, with Christian Benteke at kick-off, lost 1-0 on Manchester United’s lawn on Sunday afternoon on behalf of Matchday 15 of the Premier League. The only goal of the game was scored by Fred in the 77th minute. A short victory which allows the Mancuniens to move up to 6th place with 24 points. Brilliant during the week against Arsenal, Cristiano Ronaldo has not repeated such a performance. Facing Crystal Palace, the Mancuniens were able to count on Fred to win the three points. The Brazilian was in the right place to propel into the nets an offering from Mason Greenwood (77th, 1-0).

On the Crystal Palace side, Christian Benteke was replaced in the 67th minute. This is the third consecutive defeat in the league for the Red Devil. Crystal Palace remains stuck in 12th place with 16 units.

GERMANY:

VfB Stuttgart and Hertha Berlin, with Oral Mangala and Dedryck Boyata on both sides, parted back to back 2-2 on Sunday afternoon as part of Matchday 14 of the Bundesliga. Woe to the loser for this low ranking meeting between VfB Stuttgart, 13 points, and Hertha Berlin, 14 points, before kick-off.

The match started off brilliantly for Orel Mangala and his teammates, as Stuttgart led 2-0 after 20 minutes of play thanks to Omar Marmoush (15th, 1-0) and Philipp Forster (19th, 2-0).

The Hertha would come back in the meeting via a double from Stevan Jovetic (40th and 76th) who saved a point for the visitors.

Orel Mangala remained on the pitch for 75 minutes for Stuttgart, while Dedryck Boyata did not leave the pitch in the Hertha Berlin camp.

In the standings, status quo between the two teams: Hertha Berlin is 14th with 15 points, just ahead of Stuttgart, 14 units.

We would love to give thanks to the writer of this article for this awesome material

Belgians abroad: Christian Benteke and Crystal Palace beaten, no winner between Mangala and Boyata

" } ["summary"]=> string(733) "FRANCE: By winning 0-5 in Saint-Etienne on Sunday as part of the 17th day of Ligue 1, Rennes (without Doku) took second place (31 points) in the French championship 11 units from PSG. To take advantage of Marseille’s misstep against Brest, Bruno Génésio, who attended the match from the stands, aligned Martin Terrier and Gaëtan ... Read more" ["atom_content"]=> string(5611) "

FRANCE:

By winning 0-5 in Saint-Etienne on Sunday as part of the 17th day of Ligue 1, Rennes (without Doku) took second place (31 points) in the French championship 11 units from PSG. To take advantage of Marseille’s misstep against Brest, Bruno Génésio, who attended the match from the stands, aligned Martin Terrier and Gaëtan Laborde as an attacking duo. After wasting a great opportunity on a pass from Laborde (5th), Terrier scored twice (22nd, 28th). Rennes took even more distance thanks to an autogoal from Yvann Maçon (45th, 0-3). On the restart, Terrier (48th, 0-4) and reservist Chimuanya Ugochukwu (83rd, 0-5) stunned the Greens a little more, who remain bottom of the standings (12 points).

AS Monaco, with 15 minutes Eliot Matazo, won 4-0 against FC Metz on Sunday afternoon for the 17th day of Ligue 1. A success which places the Monegasques in 6th place with 26 points. On the bench at kick-off, Eliot Matazo returned to the game in the 75th minute while his teammates were already leading 3-0. Sofiane Diop opened the scoring very early in the game (2nd, 1-0), before Kevin Volland doubled the score on a penalty shortly before half-time (44th, 2-0). Portugal’s Gelson Martins scored the third goal in the 57th.

The inevitable Wissam Ben Yedder was in charge of giving the score its final pace by planting the last achievement of his own (87th, 4-0).

At the same time, Reims lost 1-2 on their lawn against Angers. Wout Faes played the entire game for the Rémois, while Thomas Foket gave up his place ten minutes from time.

With this setback, Reims stagnated in 14th place with 19 units.

ITALY:

In Italy, Bologna facing Fiorentina. Among the visited, Arthur Theate played the entire match on the left side of the three-way defense and was warned for a foul on Nico Gonzalez (50th). At the start of the meeting, the Bolognese waited in their camp even if the Florentine goalkeeper, Pietro Terracciano, had to focus on a center from Theate (13th). In the middle of the period, the Bolognese began to be more threatening but on a against Youssef Maleh punished them (33rd, 0-1). But with a volley from the left, Musa Barrow brought the equality (42nd, 1-1). On the resumption, Cristiano Biraghi, on free kick (52nd, 1-2) and Dusan Vlahovic, on penalty, (67th, 1-3) gave air to the Tuscans, who nevertheless accused the blow on a strike deviated from Aaron Hickey (83rd, 2-3). In the standings, Fiorentina climbs to 5th position (27 points) and Bologna is 8th (24 points).

NETHERLANDS:

In the Netherlands, Waalwijk and his Belgian colony won 2-1 against Nijmegen. Shawn Asewoye and Dario Van den Buijs played the whole match, Lennerd Daneels came out (71st), Sebbe Augustijns got on the game (46th) while Thierry Lutonda and Jens Teuckens, the reserve goalkeeper, remained on the bench. After 15 days, Waalwijk is 15th (15 points) and Nijmegen 11th (19 points).

ENGLAND:

Crystal Palace, with Christian Benteke at kick-off, lost 1-0 on Manchester United’s lawn on Sunday afternoon on behalf of Matchday 15 of the Premier League. The only goal of the game was scored by Fred in the 77th minute. A short victory which allows the Mancuniens to move up to 6th place with 24 points. Brilliant during the week against Arsenal, Cristiano Ronaldo has not repeated such a performance. Facing Crystal Palace, the Mancuniens were able to count on Fred to win the three points. The Brazilian was in the right place to propel into the nets an offering from Mason Greenwood (77th, 1-0).

On the Crystal Palace side, Christian Benteke was replaced in the 67th minute. This is the third consecutive defeat in the league for the Red Devil. Crystal Palace remains stuck in 12th place with 16 units.

GERMANY:

VfB Stuttgart and Hertha Berlin, with Oral Mangala and Dedryck Boyata on both sides, parted back to back 2-2 on Sunday afternoon as part of Matchday 14 of the Bundesliga. Woe to the loser for this low ranking meeting between VfB Stuttgart, 13 points, and Hertha Berlin, 14 points, before kick-off.

The match started off brilliantly for Orel Mangala and his teammates, as Stuttgart led 2-0 after 20 minutes of play thanks to Omar Marmoush (15th, 1-0) and Philipp Forster (19th, 2-0).

The Hertha would come back in the meeting via a double from Stevan Jovetic (40th and 76th) who saved a point for the visitors.

Orel Mangala remained on the pitch for 75 minutes for Stuttgart, while Dedryck Boyata did not leave the pitch in the Hertha Berlin camp.

In the standings, status quo between the two teams: Hertha Berlin is 14th with 15 points, just ahead of Stuttgart, 14 units.

We would love to give thanks to the writer of this article for this awesome material

Belgians abroad: Christian Benteke and Crystal Palace beaten, no winner between Mangala and Boyata

" ["date_timestamp"]=> int(1638722214) } [8]=> array(11) { ["title"]=> string(46) "ALS therapy should target mind, not just spine" ["link"]=> string(82) "https://bofads.com/healthandscience/als-therapy-should-target-mind-not-just-spine/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 15:21:12 +0000" ["category"]=> string(43) "Health And ScienceALSmindspinetargettherapy" ["guid"]=> string(26) "https://bofads.com/?p=7811" ["description"]=> string(629) "Journal Reference: Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdinler. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy, 2021; DOI: 10.1038/s41434-021-00303-4 A new Northwestern ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4156) "

Journal Reference:

  1. Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdinler. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy, 2021; DOI: 10.1038/s41434-021-00303-4

A new Northwestern study shows the degeneration of brain motor neurons (the nerve cells in the brain that control movement of the limbs) is not merely a byproduct of the spinal motor neuron degeneration, as had been previously thought.

“We have discovered that the brain degenerates early in diseases like ALS, sends us warning signals and shows defects very early in the disease,” said lead study author Hande Ozdinler, an associate professor of neurology at Northwestern University Feinberg School of Medicine. “Therefore, we need to repair the brain motor neurons if we want long-term and effective treatment strategies. The brain is important in ALS.”

The paper will be published Dec. 2 in Gene Therapy.

ALS is a swift and fatal neurodegenerative disease that paralyzes its victims.

Upper motor neuron diseases, such as ALS, hereditary spastic paraplegia and primary lateral sclerosis affect more than 250,000 people a year in the U.S. alone. There is no cure and no effective long-term treatment strategy.

This is the first study to clearly reveal the brain motor neuron degeneration is not a consequence of spinal motor neuron degeneration but is independent of the spinal motor neuron degeneration.

The research also is the first to show that the gene UCHL1 is important for maintaining the health of brain motor neurons that are diseased due to two independent underlying causes. One is the accumulation of badly folded proteins and the other is the accumulation of sticky protein clumps inside the cells. These problems are observed in more than 90% of all ALS cases and also in other cases of upper motor neuron diseases.

“Our findings not only give legitimacy for targeting brain motor neuron health in ALS as a therapeutic intervention, it also reveals the first target gene that can help these neurons be revitalized,” Ozdinler said.

“This has huge clinical implications,” Ozdinler said. “Being able to modulate gene expression in diseased brain motor neurons in upper motor neuron disease patients is mind boggling. Since movement starts in the brain, if we can make the brain motor neurons happy and healthy, if we can boost their health and integrity with directed gene delivery, we may begin to develop personalized treatment options especially for patients with upper motor neuron disease, who currently have no effective treatment options.

Northwestern University scientists have previously identified NU-9, the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS. Now, this study reveals the importance and significance of treating upper motor neurons in ALS and identifies the first genetic target.

The next step is to determine the best dose and the best site of injection with respect to improvement of movement and reduction of disease conditions in at least two different ALS disease models. After preclinical toxicology studies, scientists will move to translate these results into a clinical trial, a process that likely will take several years.

We wish to thank the author of this article for this remarkable material

ALS therapy should target mind, not just spine

" } ["summary"]=> string(629) "Journal Reference: Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdinler. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy, 2021; DOI: 10.1038/s41434-021-00303-4 A new Northwestern ... Read more" ["atom_content"]=> string(4156) "

Journal Reference:

  1. Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdinler. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy, 2021; DOI: 10.1038/s41434-021-00303-4

A new Northwestern study shows the degeneration of brain motor neurons (the nerve cells in the brain that control movement of the limbs) is not merely a byproduct of the spinal motor neuron degeneration, as had been previously thought.

“We have discovered that the brain degenerates early in diseases like ALS, sends us warning signals and shows defects very early in the disease,” said lead study author Hande Ozdinler, an associate professor of neurology at Northwestern University Feinberg School of Medicine. “Therefore, we need to repair the brain motor neurons if we want long-term and effective treatment strategies. The brain is important in ALS.”

The paper will be published Dec. 2 in Gene Therapy.

ALS is a swift and fatal neurodegenerative disease that paralyzes its victims.

Upper motor neuron diseases, such as ALS, hereditary spastic paraplegia and primary lateral sclerosis affect more than 250,000 people a year in the U.S. alone. There is no cure and no effective long-term treatment strategy.

This is the first study to clearly reveal the brain motor neuron degeneration is not a consequence of spinal motor neuron degeneration but is independent of the spinal motor neuron degeneration.

The research also is the first to show that the gene UCHL1 is important for maintaining the health of brain motor neurons that are diseased due to two independent underlying causes. One is the accumulation of badly folded proteins and the other is the accumulation of sticky protein clumps inside the cells. These problems are observed in more than 90% of all ALS cases and also in other cases of upper motor neuron diseases.

“Our findings not only give legitimacy for targeting brain motor neuron health in ALS as a therapeutic intervention, it also reveals the first target gene that can help these neurons be revitalized,” Ozdinler said.

“This has huge clinical implications,” Ozdinler said. “Being able to modulate gene expression in diseased brain motor neurons in upper motor neuron disease patients is mind boggling. Since movement starts in the brain, if we can make the brain motor neurons happy and healthy, if we can boost their health and integrity with directed gene delivery, we may begin to develop personalized treatment options especially for patients with upper motor neuron disease, who currently have no effective treatment options.

Northwestern University scientists have previously identified NU-9, the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS. Now, this study reveals the importance and significance of treating upper motor neurons in ALS and identifies the first genetic target.

The next step is to determine the best dose and the best site of injection with respect to improvement of movement and reduction of disease conditions in at least two different ALS disease models. After preclinical toxicology studies, scientists will move to translate these results into a clinical trial, a process that likely will take several years.

We wish to thank the author of this article for this remarkable material

ALS therapy should target mind, not just spine

" ["date_timestamp"]=> int(1638717672) } [9]=> array(11) { ["title"]=> string(128) "The Ultras carolos want to rediscover the charm of the Standard-Charleroi: “In recent years, this trip has lost some flavor”" ["link"]=> string(146) "https://bofads.com/sport/the-ultras-carolos-want-to-rediscover-the-charm-of-the-standard-charleroi-in-recent-years-this-trip-has-lost-some-flavor/" ["dc"]=> array(1) { ["creator"]=> string(8) "Tim Hall" } ["pubdate"]=> string(31) "Sun, 05 Dec 2021 15:06:00 +0000" ["category"]=> string(64) "SportcaroloscharmflavorlostrediscoverStandardCharleroitripUltras" ["guid"]=> string(26) "https://bofads.com/?p=7808" ["description"]=> string(822) "Standard – Charleroi, the Walloon shock, it’s always a special match for the two teams. As a result, sometimes the demand is greater than the supply in terms of the number of tickets provided for outside supporters. In a press release, the Ultras Carolos explained (not without a touch of humor and irony) why they ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4260) "

Standard – Charleroi, the Walloon shock, it’s always a special match for the two teams. As a result, sometimes the demand is greater than the supply in terms of the number of tickets provided for outside supporters. In a press release, the Ultras Carolos explained (not without a touch of humor and irony) why they favored subscribers for this extremely important trip.

The Ultras also reminded all Carolos fans not to throw anything on the pitch that could endanger the players and encouraged them not to detonate firecrackers inside the stadium.

Finally, the Ultras were also keen to encourage their players, urging them to give everything so that the Zebras can finally win at Sclessin, which would be a first since 2008.

The Ultras carolos press release:

“Aaaah, the Standard, we have gained more since 2008. Bam, early in the morning it calms down right away. The last” face-to-face “trip to these infected lands dates back to September 29, 2019 (with an incredible 1-1 sous Karim and a still unsuccessful victory.) It is therefore after more than 2 years – with the health context that we know – that we find dry rot, still alive certainly, with a feeling of nostalgia.

It has become for us a trip – and unfortunately also for other faithful – which loses its flavor. Rivalry is one thing, and it’s part of the magic. It makes it one of the parts in Belgium – if not the most intense – where the best enemies meet in a match and in the stands where misfortune will befall the loser of the lawn (loose trophy, 6000 reprezent, we knows). And yet.

Too many social cases in our bloc these days of so-called “derbies”.

Too many guys with no knowledge of the “displacement” spirit.

Too many silent badgers with behaviors worthy of 107 or AA (your choice) or in article 60 mode.

Too many guys present to be like “place to be”.

This rivalry does not belong to these fools who have the boldness to smear our colors and piss off the world – most often once a year because it is their only trip of course – but to all groups ( well beyond ours, much broader than the ultra mentality besides) who break ass every weekend for the coat of arms, even if it means being 114 at the Cercle de Bruges.

Reason for our voluntary limitation of space to cards only. And we are delighted. Quality is better than quantity.

Finally, in the register that you have all followed at the level of the fight for a more liberated pyrotechnics, we ask you to respect the following and simple attitudes: nothing on the field, nothing on the adversaries, nothing on the players. No torches, cups or IUDs. Given the proximity of this forum in sardine mode, we discourage the use of firecrackers for the hearing health of all. We are not your mothers or the police relay. We just want this shock to be well managed, intense, fanatic if necessary, but respecting everyone’s safety. Thank you.

As for the zebras if they have not understood that this match must release all their rage, all their fighting spirit … well we encourage them to switch to the console to perhaps finally win this shock.

Good trip everyone, put on your mask (we told you already before the Covid-19), it’s Liège … and that’s where many epidemics started historically (sisi!) . “

We would like to give thanks to the author of this write-up for this amazing web content

The Ultras carolos want to rediscover the charm of the Standard-Charleroi: “In recent years, this trip has lost some flavor”

" } ["summary"]=> string(822) "Standard – Charleroi, the Walloon shock, it’s always a special match for the two teams. As a result, sometimes the demand is greater than the supply in terms of the number of tickets provided for outside supporters. In a press release, the Ultras Carolos explained (not without a touch of humor and irony) why they ... Read more" ["atom_content"]=> string(4260) "

Standard – Charleroi, the Walloon shock, it’s always a special match for the two teams. As a result, sometimes the demand is greater than the supply in terms of the number of tickets provided for outside supporters. In a press release, the Ultras Carolos explained (not without a touch of humor and irony) why they favored subscribers for this extremely important trip.

The Ultras also reminded all Carolos fans not to throw anything on the pitch that could endanger the players and encouraged them not to detonate firecrackers inside the stadium.

Finally, the Ultras were also keen to encourage their players, urging them to give everything so that the Zebras can finally win at Sclessin, which would be a first since 2008.

The Ultras carolos press release:

“Aaaah, the Standard, we have gained more since 2008. Bam, early in the morning it calms down right away. The last” face-to-face “trip to these infected lands dates back to September 29, 2019 (with an incredible 1-1 sous Karim and a still unsuccessful victory.) It is therefore after more than 2 years – with the health context that we know – that we find dry rot, still alive certainly, with a feeling of nostalgia.

It has become for us a trip – and unfortunately also for other faithful – which loses its flavor. Rivalry is one thing, and it’s part of the magic. It makes it one of the parts in Belgium – if not the most intense – where the best enemies meet in a match and in the stands where misfortune will befall the loser of the lawn (loose trophy, 6000 reprezent, we knows). And yet.

Too many social cases in our bloc these days of so-called “derbies”.

Too many guys with no knowledge of the “displacement” spirit.

Too many silent badgers with behaviors worthy of 107 or AA (your choice) or in article 60 mode.

Too many guys present to be like “place to be”.

This rivalry does not belong to these fools who have the boldness to smear our colors and piss off the world – most often once a year because it is their only trip of course – but to all groups ( well beyond ours, much broader than the ultra mentality besides) who break ass every weekend for the coat of arms, even if it means being 114 at the Cercle de Bruges.

Reason for our voluntary limitation of space to cards only. And we are delighted. Quality is better than quantity.

Finally, in the register that you have all followed at the level of the fight for a more liberated pyrotechnics, we ask you to respect the following and simple attitudes: nothing on the field, nothing on the adversaries, nothing on the players. No torches, cups or IUDs. Given the proximity of this forum in sardine mode, we discourage the use of firecrackers for the hearing health of all. We are not your mothers or the police relay. We just want this shock to be well managed, intense, fanatic if necessary, but respecting everyone’s safety. Thank you.

As for the zebras if they have not understood that this match must release all their rage, all their fighting spirit … well we encourage them to switch to the console to perhaps finally win this shock.

Good trip everyone, put on your mask (we told you already before the Covid-19), it’s Liège … and that’s where many epidemics started historically (sisi!) . “

We would like to give thanks to the author of this write-up for this amazing web content

The Ultras carolos want to rediscover the charm of the Standard-Charleroi: “In recent years, this trip has lost some flavor”

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