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Association between children conceived via infertility treatments and education and mental health outcomes
No more binge consuming: Signal pathway in the brain that controls food intake discovered
Paola Rojas confirmed having a new partner: ?Not so lonely?
Andrea Legarreta, does your marriage falter?, flirts in full Today
We tell you everything: why these celebrities are part of the Ferrari blacklist
Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data
Maternal mortality jumped during COVID-19 pandemic
Strategies beyond recycling to bolster circular economy for solar and battery technologies
Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats
Many pain medications can be used for spine-related pain in older adults

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                    [title] => Association between children conceived via infertility treatments and education and mental health outcomes
                    [link] => https://fastmediaservice.com/association-between-children-conceived-via-infertility-treatments-and-education-and-mental-health-outcomes/
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                            [creator] => Michael Cowan
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                    [pubdate] => Wed, 29 Jun 2022 12:05:12 +0000
                    [category] => scienceAssociationchildrenconceivededucationhealthinfertilitymentaloutcomestreatments
                    [guid] => https://fastmediaservice.com/?p=2176
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Journal Reference: Hanna Remes, Maria Palma Carvajal, Riina Peltonen, Pekka Martikainen, Alice Goisis. The Well-Being of Adolescents Conceived Through Medically Assisted Reproduction: A Population-Level and Within-Family Analysis. European Journal of Population, 2022; DOI: 10.1007/s10680-022-09623-6 The researchers say the correlation for mental health is only observed when the social demographics of children?s families are taken into ... Read more

The post Association between children conceived via infertility treatments and education and mental health outcomes first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Hanna Remes, Maria Palma Carvajal, Riina Peltonen, Pekka Martikainen, Alice Goisis. The Well-Being of Adolescents Conceived Through Medically Assisted Reproduction: A Population-Level and Within-Family Analysis. European Journal of Population, 2022; DOI: 10.1007/s10680-022-09623-6

The researchers say the correlation for mental health is only observed when the social demographics of children?s families are taken into account, and that there is no evidence to suggest the MAR treatment itself is the source of association for mental health.

Published in the European Journal of Population, the observational study explores the link between MAR ? including techniques such as IVF treatment, artificial insemination and ovulation induction ? and young people?s educational outcomes and mental health.

The researchers used administrative records on 280,682 Finnish children born between 1995 and 2000, and compared a range of educational and mental health outcomes among adolescents aged between 16 and 18 who were conceived naturally (266,925) and through MAR (13,757).

The researchers found that adolescents conceived by MAR performed better in school, were less likely to drop out and were at a lower risk of not being in education or employment or leaving home early compared to naturally conceived adolescents. These differences mostly disappeared when family circumstances were accounted for, suggesting that socioeconomic background is an important factor in explaining this advantage.

The researchers also found that adolescents conceived via MAR were not more likely to experience mental health problems. However, after accounting for family circumstances, the study revealed that they were at an increased risk of developing a mental disorder ? particularly anxiety or depression ? with around 10 per cent of MAR conceived adolescents compared to nine per cent of naturally conceived adolescents receiving a mental health diagnosis between ages 16-18.

Researchers say, while small as a percentage, this difference in risk is comparable to the difference between children of secondary and tertiary educated parents. Although modest, the findings based on several indicators of mental health were consistent. Nonetheless, there is no evidence to suggest MAR is the source of association ? other family characteristics could explain it.

This increased risk was also present when comparing adolescents conceived through MAR with their naturally conceived siblings, a finding that researchers say adds robustness to the study, as the team were able to control for family characteristics which are otherwise unobserved.

Co-author Dr Alice Goisis (UCL Centre for Longitudinal Studies) said: ?We explicitly put a lot of focus on the social demographics of families who conceived through medically assisted reproduction ? and our findings underscore the importance of integrating this perspective in studies of medically assisted reproduction and its consequences.

?What we?re seeing here is mostly reassuring; children conceived through medically assisted reproduction do better overall and are in fact not more disadvantaged in terms of mental health outcomes. However, the fact that we observe an increased risk of mental health disorders once we account for family characteristics could be a cause for concern and merits further attention in future research.?

The study is thought to be the first to examine links between mode of conception and mental health and social outcomes in adolescence for the same group of children; while previous research has focused on birth and early life outcomes of MAR children, less is known about what happens when they grow older.

The authors note that MAR children are more likely to come from better off families who may provide children with resources (financial, time and emotional) that benefit their educational outcomes. However, they could also suggest that difficulties conceiving may expose parents to mental health issues, which could have impacted their children by putting them at greater risk of psychological distress.

Lead author, Dr Hanna Remes (University of Helsinki), said: ?Whilst we don?t have the data to explain why those born by medically assisted reproduction are at slightly higher risk of mental health disorders, we believe that this may be due to different mechanisms.

?The fact that MAR-conceived children tend to be the first-born ? around 60 per cent of the children in the study ? explained some of the excess risks. It is also possible that because of the process they went through, parents of children conceived by IVF, for example, may have been exposed mental health problems, such as depression and anxiety, which may, in turn, have put the children themselves at higher risk of having mental health problems.

?Alternatively, they may be more apprehensive about their child?s welfare and more likely to make sure their child attends hospital or visits the doctor ? and therefore these children may be more likely to get a diagnosis for certain conditions.?

The researchers note that, as the oldest child conceived by IVF is now 43, this area of research is relatively new and underexplored. They stress that, given the rise in the number of children being conceived via MAR for various reasons, it is vital that we understand the longer-term consequences on children and young people.

Association between children conceived via infertility treatments and education and mental health outcomes

The post Association between children conceived via infertility treatments and education and mental health outcomes first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Hanna Remes, Maria Palma Carvajal, Riina Peltonen, Pekka Martikainen, Alice Goisis. The Well-Being of Adolescents Conceived Through Medically Assisted Reproduction: A Population-Level and Within-Family Analysis. European Journal of Population, 2022; DOI: 10.1007/s10680-022-09623-6 The researchers say the correlation for mental health is only observed when the social demographics of children?s families are taken into ... Read more

The post Association between children conceived via infertility treatments and education and mental health outcomes first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Hanna Remes, Maria Palma Carvajal, Riina Peltonen, Pekka Martikainen, Alice Goisis. The Well-Being of Adolescents Conceived Through Medically Assisted Reproduction: A Population-Level and Within-Family Analysis. European Journal of Population, 2022; DOI: 10.1007/s10680-022-09623-6

The researchers say the correlation for mental health is only observed when the social demographics of children?s families are taken into account, and that there is no evidence to suggest the MAR treatment itself is the source of association for mental health.

Published in the European Journal of Population, the observational study explores the link between MAR ? including techniques such as IVF treatment, artificial insemination and ovulation induction ? and young people?s educational outcomes and mental health.

The researchers used administrative records on 280,682 Finnish children born between 1995 and 2000, and compared a range of educational and mental health outcomes among adolescents aged between 16 and 18 who were conceived naturally (266,925) and through MAR (13,757).

The researchers found that adolescents conceived by MAR performed better in school, were less likely to drop out and were at a lower risk of not being in education or employment or leaving home early compared to naturally conceived adolescents. These differences mostly disappeared when family circumstances were accounted for, suggesting that socioeconomic background is an important factor in explaining this advantage.

The researchers also found that adolescents conceived via MAR were not more likely to experience mental health problems. However, after accounting for family circumstances, the study revealed that they were at an increased risk of developing a mental disorder ? particularly anxiety or depression ? with around 10 per cent of MAR conceived adolescents compared to nine per cent of naturally conceived adolescents receiving a mental health diagnosis between ages 16-18.

Researchers say, while small as a percentage, this difference in risk is comparable to the difference between children of secondary and tertiary educated parents. Although modest, the findings based on several indicators of mental health were consistent. Nonetheless, there is no evidence to suggest MAR is the source of association ? other family characteristics could explain it.

This increased risk was also present when comparing adolescents conceived through MAR with their naturally conceived siblings, a finding that researchers say adds robustness to the study, as the team were able to control for family characteristics which are otherwise unobserved.

Co-author Dr Alice Goisis (UCL Centre for Longitudinal Studies) said: ?We explicitly put a lot of focus on the social demographics of families who conceived through medically assisted reproduction ? and our findings underscore the importance of integrating this perspective in studies of medically assisted reproduction and its consequences.

?What we?re seeing here is mostly reassuring; children conceived through medically assisted reproduction do better overall and are in fact not more disadvantaged in terms of mental health outcomes. However, the fact that we observe an increased risk of mental health disorders once we account for family characteristics could be a cause for concern and merits further attention in future research.?

The study is thought to be the first to examine links between mode of conception and mental health and social outcomes in adolescence for the same group of children; while previous research has focused on birth and early life outcomes of MAR children, less is known about what happens when they grow older.

The authors note that MAR children are more likely to come from better off families who may provide children with resources (financial, time and emotional) that benefit their educational outcomes. However, they could also suggest that difficulties conceiving may expose parents to mental health issues, which could have impacted their children by putting them at greater risk of psychological distress.

Lead author, Dr Hanna Remes (University of Helsinki), said: ?Whilst we don?t have the data to explain why those born by medically assisted reproduction are at slightly higher risk of mental health disorders, we believe that this may be due to different mechanisms.

?The fact that MAR-conceived children tend to be the first-born ? around 60 per cent of the children in the study ? explained some of the excess risks. It is also possible that because of the process they went through, parents of children conceived by IVF, for example, may have been exposed mental health problems, such as depression and anxiety, which may, in turn, have put the children themselves at higher risk of having mental health problems.

?Alternatively, they may be more apprehensive about their child?s welfare and more likely to make sure their child attends hospital or visits the doctor ? and therefore these children may be more likely to get a diagnosis for certain conditions.?

The researchers note that, as the oldest child conceived by IVF is now 43, this area of research is relatively new and underexplored. They stress that, given the rise in the number of children being conceived via MAR for various reasons, it is vital that we understand the longer-term consequences on children and young people.

Association between children conceived via infertility treatments and education and mental health outcomes

The post Association between children conceived via infertility treatments and education and mental health outcomes first appeared on Fastmediaservice.

[date_timestamp] => 1656504312 ) [1] => Array ( [title] => No more binge consuming: Signal pathway in the brain that controls food intake discovered [link] => https://fastmediaservice.com/no-more-binge-consuming-signal-pathway-in-the-brain-that-controls-food-intake-discovered/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 10:45:38 +0000 [category] => scienceBingebrainconsumingcontrolsdiscoveredfoodintakepathwaySignal [guid] => https://fastmediaservice.com/?p=2174 [description] =>

Journal Reference: Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt. ... Read more

The post No more binge consuming: Signal pathway in the brain that controls food intake discovered first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nature Metabolism, 2022; 4 (6): 683 DOI: 10.1038/s42255-022-00589-7

Eating disorders and especially obesity are one of the most common causes of a variety of diseases in industrialized societies worldwide, especially cardiovascular diseases with permanent disabilities or fatal outcomes such as heart attacks, diabetes, or strokes. The Robert Koch Institute reported in 2021 that 67 per cent of men and 53 percent of women in Germany are overweight. 23 per cent of adults are severely overweight (obese). Attempts to influence eating behaviour with medication have so far proved ineffective. A novel therapy that modulates the excitability of networks that control eating behaviour would be a decisive step towards controlling this widespread obesity.

The research team found an increased rate of obesity and the attendant type II diabetes in people with impaired synaptic LPA signalling. A group led by Professor Johannes Vogt (Faculty of Medicine, University of Cologne), Professor Robert Nitsch (Faculty of Medicine, University of Münster) und Professor Thomas Horvath (Yale School of Medicine, New Haven, USA) has now shown that control of the excitability of neurons in the cerebral cortex by LPA plays an essential role in the control of eating behaviour: AgRP neurons regulate the amount of lysophosphatidylcholine (LPC) in the blood. Through active transport, LPC reaches the brain, where it is converted by the enzyme autotaxin (ATX) into LPA, which is active at the synapse. Synaptic LPA signals stimulate specific networks in the brain, thus leading to increased food intake.

In the mouse model, after a period of fasting an increase in LPC in the blood led to an increase in stimulating LPA in the brain. These mice showed typical food-seeking behaviour. Both could be normalized by administrating autotaxin inhibitors. Obese mice, on the other hand, lost weight when these inhibitors were administered continuously. Johannes Vogt explained: ?We saw a significant reduction in excessive food intake and obesity through gene mutation and pharmacological inhibition of ATX. Our fundamental findings on the LPA-controlled excitability of the brain, which we have worked on for years, therefore also play a central role for eating behaviour.? Robert Nitsch sees the findings as an important step towards new drug development: ?The data show that people with a disturbed synaptic LPA signalling pathway are more likely to be overweight and suffer from type II diabetes. This is a strong indication of a possible therapeutic success of ATX inhibitors, which we are currently developing together with the Hans Knöll Institute in Jena for use in humans.?

These findings on the excitation control of neuronal networks in eating behaviour through lysophospholipids and the new therapeutic possibilities they suggest could in future contribute not only to treating eating disorders, but also neurological and psychiatric illnesses.

No more binge consuming: Signal pathway in the brain that controls food intake discovered

The post No more binge consuming: Signal pathway in the brain that controls food intake discovered first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt. ... Read more

The post No more binge consuming: Signal pathway in the brain that controls food intake discovered first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nature Metabolism, 2022; 4 (6): 683 DOI: 10.1038/s42255-022-00589-7

Eating disorders and especially obesity are one of the most common causes of a variety of diseases in industrialized societies worldwide, especially cardiovascular diseases with permanent disabilities or fatal outcomes such as heart attacks, diabetes, or strokes. The Robert Koch Institute reported in 2021 that 67 per cent of men and 53 percent of women in Germany are overweight. 23 per cent of adults are severely overweight (obese). Attempts to influence eating behaviour with medication have so far proved ineffective. A novel therapy that modulates the excitability of networks that control eating behaviour would be a decisive step towards controlling this widespread obesity.

The research team found an increased rate of obesity and the attendant type II diabetes in people with impaired synaptic LPA signalling. A group led by Professor Johannes Vogt (Faculty of Medicine, University of Cologne), Professor Robert Nitsch (Faculty of Medicine, University of Münster) und Professor Thomas Horvath (Yale School of Medicine, New Haven, USA) has now shown that control of the excitability of neurons in the cerebral cortex by LPA plays an essential role in the control of eating behaviour: AgRP neurons regulate the amount of lysophosphatidylcholine (LPC) in the blood. Through active transport, LPC reaches the brain, where it is converted by the enzyme autotaxin (ATX) into LPA, which is active at the synapse. Synaptic LPA signals stimulate specific networks in the brain, thus leading to increased food intake.

In the mouse model, after a period of fasting an increase in LPC in the blood led to an increase in stimulating LPA in the brain. These mice showed typical food-seeking behaviour. Both could be normalized by administrating autotaxin inhibitors. Obese mice, on the other hand, lost weight when these inhibitors were administered continuously. Johannes Vogt explained: ?We saw a significant reduction in excessive food intake and obesity through gene mutation and pharmacological inhibition of ATX. Our fundamental findings on the LPA-controlled excitability of the brain, which we have worked on for years, therefore also play a central role for eating behaviour.? Robert Nitsch sees the findings as an important step towards new drug development: ?The data show that people with a disturbed synaptic LPA signalling pathway are more likely to be overweight and suffer from type II diabetes. This is a strong indication of a possible therapeutic success of ATX inhibitors, which we are currently developing together with the Hans Knöll Institute in Jena for use in humans.?

These findings on the excitation control of neuronal networks in eating behaviour through lysophospholipids and the new therapeutic possibilities they suggest could in future contribute not only to treating eating disorders, but also neurological and psychiatric illnesses.

No more binge consuming: Signal pathway in the brain that controls food intake discovered

The post No more binge consuming: Signal pathway in the brain that controls food intake discovered first appeared on Fastmediaservice.

[date_timestamp] => 1656499538 ) [2] => Array ( [title] => Paola Rojas confirmed having a new partner: ?Not so lonely? [link] => https://fastmediaservice.com/paola-rojas-confirmed-having-a-new-partner-not-so-lonely/ [dc] => Array ( [creator] => Michael Steiner ) [pubdate] => Wed, 29 Jun 2022 09:31:29 +0000 [category] => Latest NewsconfirmedlonelyPaolapartnerRojas [guid] => https://fastmediaservice.com/?p=2171 [description] =>

Paola Rojas confirmed that she has a boyfriend, for the first time after her divorce with Zague (Photo: Instagram/@netasdivinastv) Paola Rojas was first caught with her new partner heading to their vacations, this after the journalist divorced Luis Roberto Alves Zague more than three years ago. After having been romantically related to different actors and ... Read more

The post Paola Rojas confirmed having a new partner: ?Not so lonely? first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Paola Rojas confirmed that she has a boyfriend, for the first time after her divorce with Zague (Photo: Instagram/@netasdivinastv)

Paola Rojas was first caught with her new partner heading to their vacations, this after the journalist divorced Luis Roberto Alves Zague more than three years ago.

After having been romantically related to different actors and singers, Paola Rojas was finally seen with her new boyfriend, whom she did not want to talk about in detail. The communicator confirmed that decided to give himself a new chance at love after going through a difficult separation with Zague.

And it is that Rojas was captured by various means, including windowing, at the Mexico City Airport with her new partner; He did not want to approach the microphones, but the journalist did and even answered some questions about her private life.

Paola, when questioned about how she is sentimentally, replied: ?I’m very well, in all aspects. I think in life you have to enjoy every minute and that, you have to live fully?.

Paola Rojas did not hide her happiness at being able to share vacations with her boyfriend (Photo: screenshot/Instagram)
Paola Rojas did not hide her happiness at being able to share vacations with her boyfriend (Photo: screenshot/Instagram)

She also mentioned that she was going to take a flight to enjoy a short vacation, in which she would not be alone.

“I wish they were long vacations, I am needing them, I do take rest, but for the moment there will be no such opportunity (…) For now, I’m going away for a weekend… not so alonenot so alone ?, he commented happily before the cameras.

Since her divorce, Paola Rojas has been paired with different celebrities, including Beto Cuevas, with whom however, she denied her alleged romance weeks after the rumors began. And it is that the journalist would have been seen very happy with the Chilean.

Previously, due to his close relationship with John SolerRojas was also related to him, however, the celebrities have maintained a close friendship for several years, so neither of them bothered to deny their alleged courtship.

According to what was circulated on social networks, Beto Cuevas and Paola Rojas would have been seen very "in love" during an interview (Photo: Instagram/@paolarojas)
As circulated on social networks, Beto Cuevas and Paola Rojas would have been seen very “in love” during an interview (Photo: Instagram/@paolarojas)

Also, it was rumored that he would have an affair with Kalimbabut it was the singer who was responsible for denying such information.

Who could have been accompanying Paola Rojas on her short vacation is Marcelo Imposti, with whom she has been seen at different events. The couple has been photographed mainly at the Mexican Tennis Open since 2019, although at that time neither had spoken of a possible romance.

Imposti is a 56-year-old Argentine businessman and CEO of Grupo Publica, an advertising company that has worked for companies such as Unilever, Disney, Adidas and more, according to his website. It is also known that Marcelo studied architecture at the University of Belgrano, in Buenos Aires. Both he and Paola have gone through difficult times in love, since Imposti is also divorced.

Zague and Paola Rojas divorced because of the video that circulated the exbutbolista (Photo: File)
Zague and Paola Rojas divorced because of the video that circulated the exbutbolista (Photo: File)

It was in 2018 when Paola Rojas experienced what she has called a “mass humiliation”since an intimate video of her then-husband, Zague, was leaked, which would insinuate that she was being unfaithful. As the communicator has come to comment, she was the victim of social media violenceas he received many ridicules and negative comments when the controversy began.

In the program Divine Net She shared that what affected her the most at that time was not how the relationship with her husband ended, but the way Internet users criticized her and made assumptions about her private life.

After the video circulated on the internet, Zague and Rojas they announced their divorce. Currently, as the journalist has mentioned, her relationship with her ex-husband is “affectionate” thanks to the good times they enjoyed as a couple.

KEEP READING:

Paola Rojas confirmed having a new partner: “Not so lonely”

The post Paola Rojas confirmed having a new partner: ?Not so lonely? first appeared on Fastmediaservice.

) [summary] =>

Paola Rojas confirmed that she has a boyfriend, for the first time after her divorce with Zague (Photo: Instagram/@netasdivinastv) Paola Rojas was first caught with her new partner heading to their vacations, this after the journalist divorced Luis Roberto Alves Zague more than three years ago. After having been romantically related to different actors and ... Read more

The post Paola Rojas confirmed having a new partner: ?Not so lonely? first appeared on Fastmediaservice.

[atom_content] =>

Paola Rojas confirmed that she has a boyfriend, for the first time after her divorce with Zague (Photo: Instagram/@netasdivinastv)

Paola Rojas was first caught with her new partner heading to their vacations, this after the journalist divorced Luis Roberto Alves Zague more than three years ago.

After having been romantically related to different actors and singers, Paola Rojas was finally seen with her new boyfriend, whom she did not want to talk about in detail. The communicator confirmed that decided to give himself a new chance at love after going through a difficult separation with Zague.

And it is that Rojas was captured by various means, including windowing, at the Mexico City Airport with her new partner; He did not want to approach the microphones, but the journalist did and even answered some questions about her private life.

Paola, when questioned about how she is sentimentally, replied: ?I’m very well, in all aspects. I think in life you have to enjoy every minute and that, you have to live fully?.

Paola Rojas did not hide her happiness at being able to share vacations with her boyfriend (Photo: screenshot/Instagram)
Paola Rojas did not hide her happiness at being able to share vacations with her boyfriend (Photo: screenshot/Instagram)

She also mentioned that she was going to take a flight to enjoy a short vacation, in which she would not be alone.

“I wish they were long vacations, I am needing them, I do take rest, but for the moment there will be no such opportunity (…) For now, I’m going away for a weekend… not so alonenot so alone ?, he commented happily before the cameras.

Since her divorce, Paola Rojas has been paired with different celebrities, including Beto Cuevas, with whom however, she denied her alleged romance weeks after the rumors began. And it is that the journalist would have been seen very happy with the Chilean.

Previously, due to his close relationship with John SolerRojas was also related to him, however, the celebrities have maintained a close friendship for several years, so neither of them bothered to deny their alleged courtship.

According to what was circulated on social networks, Beto Cuevas and Paola Rojas would have been seen very "in love" during an interview (Photo: Instagram/@paolarojas)
As circulated on social networks, Beto Cuevas and Paola Rojas would have been seen very “in love” during an interview (Photo: Instagram/@paolarojas)

Also, it was rumored that he would have an affair with Kalimbabut it was the singer who was responsible for denying such information.

Who could have been accompanying Paola Rojas on her short vacation is Marcelo Imposti, with whom she has been seen at different events. The couple has been photographed mainly at the Mexican Tennis Open since 2019, although at that time neither had spoken of a possible romance.

Imposti is a 56-year-old Argentine businessman and CEO of Grupo Publica, an advertising company that has worked for companies such as Unilever, Disney, Adidas and more, according to his website. It is also known that Marcelo studied architecture at the University of Belgrano, in Buenos Aires. Both he and Paola have gone through difficult times in love, since Imposti is also divorced.

Zague and Paola Rojas divorced because of the video that circulated the exbutbolista (Photo: File)
Zague and Paola Rojas divorced because of the video that circulated the exbutbolista (Photo: File)

It was in 2018 when Paola Rojas experienced what she has called a “mass humiliation”since an intimate video of her then-husband, Zague, was leaked, which would insinuate that she was being unfaithful. As the communicator has come to comment, she was the victim of social media violenceas he received many ridicules and negative comments when the controversy began.

In the program Divine Net She shared that what affected her the most at that time was not how the relationship with her husband ended, but the way Internet users criticized her and made assumptions about her private life.

After the video circulated on the internet, Zague and Rojas they announced their divorce. Currently, as the journalist has mentioned, her relationship with her ex-husband is “affectionate” thanks to the good times they enjoyed as a couple.

KEEP READING:

Paola Rojas confirmed having a new partner: “Not so lonely”

The post Paola Rojas confirmed having a new partner: ?Not so lonely? first appeared on Fastmediaservice.

[date_timestamp] => 1656495089 ) [3] => Array ( [title] => Andrea Legarreta, does your marriage falter?, flirts in full Today [link] => https://fastmediaservice.com/andrea-legarreta-does-your-marriage-falter-flirts-in-full-today/ [dc] => Array ( [creator] => Michael Steiner ) [pubdate] => Wed, 29 Jun 2022 09:13:07 +0000 [category] => Latest NewsAndreafalterflirtsfullLegarretamarriagetoday [guid] => https://fastmediaservice.com/?p=2169 [description] =>

Andrea Legarreta, does your marriage falter?, flirts in full Today | Facebook Coquette!, Andrea Legarreta He could not hide his most flirtatious side and came out in the middle of the Hoy Program, completely forgetting his marriage to the singer Eric Rubín, with whom he has two daughters. The beloved driver Today was completely distracted ... Read more

The post Andrea Legarreta, does your marriage falter?, flirts in full Today first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Coquette!, Andrea Legarreta He could not hide his most flirtatious side and came out in the middle of the Hoy Program, completely forgetting his marriage to the singer Eric Rubín, with whom he has two daughters.

The beloved driver Today was completely distracted after watching Tońita and her dance partner, Spanish actor Jorge Loza, dance, which included a “shirt off”.

The handsome actor danced for the second time with the former member of The Academy after his original partner, Chao, said goodbye to the competition of the reality star of the program today.

It may interest you: Cristiano Ronaldo, beautiful niece comes to light and the networks go crazy

Without a doubt, the track was altered at the moment that Loza revealed the evidence of his hard training on stage and with tremendous movements next to the Negra de Oro, which is why Andrea Legarreta He couldn’t hide his nervousness.

With a “I don’t know what I was going to tell them”, Galilea Montijo’s friend and colleague assured that she forgot her criticism after seeing how the handsome actor took off his shirt and soon filled Jorge Loza with compliments and then thanked him the hard work you are surely doing in the gym.

Legarreta confessed that she has known the celebrity from the reality show Guerreros 2020 and the difference in her anatomy from that reality show to today, which is part of Las Estrellas Bailan en Hoy, is evident.

The beauty of the actor definitely altered many, because even Emma Pulido, who acts as the Iron Judge, forgot this role and full of compliments to the handsome famous man, assuring that even she had a “joyful eye”.

Unfortunately, this broadcast of the reality show program today It has stood out more for the injuries and altercations that celebrities have had, especially in the rehearsals that are carried out in the forums.
Marie Claire, José Manuel Figueroa’s partner had to leave on an emergency stretcher after a heavy fall in a load; who has also shared ending up on the ground in rehearsals is the beautiful Lis Vega.

Follow us on

I have a degree in Nutrition from the Autonomous University of Durango. I began my career as a journalist at El Debate Mazatlán in March 2017, working on international stories for the debate.com.mx website. Subsequently, Grupo Debate began to focus on various regions of the country, so I wrote notes and managed the Debate Guadalajara Facebook page. Being a company in constant movement, I moved to general content writing and currently I work as Web Editor of the Show News vertical, which I have taken since its launch on June 8, 2019. Show News had an explosive start and ascent. In the time that I have developed in this great work team, I have been part of the constant renewal of El Debate, all with the aim of truthfully informing and adapting to the needs of both local and international followers.

see more

Andrea Legarreta, does your marriage falter?, flirts in full Today

The post Andrea Legarreta, does your marriage falter?, flirts in full Today first appeared on Fastmediaservice.

) [summary] =>

Andrea Legarreta, does your marriage falter?, flirts in full Today | Facebook Coquette!, Andrea Legarreta He could not hide his most flirtatious side and came out in the middle of the Hoy Program, completely forgetting his marriage to the singer Eric Rubín, with whom he has two daughters. The beloved driver Today was completely distracted ... Read more

The post Andrea Legarreta, does your marriage falter?, flirts in full Today first appeared on Fastmediaservice.

[atom_content] =>

Coquette!, Andrea Legarreta He could not hide his most flirtatious side and came out in the middle of the Hoy Program, completely forgetting his marriage to the singer Eric Rubín, with whom he has two daughters.

The beloved driver Today was completely distracted after watching Tońita and her dance partner, Spanish actor Jorge Loza, dance, which included a “shirt off”.

The handsome actor danced for the second time with the former member of The Academy after his original partner, Chao, said goodbye to the competition of the reality star of the program today.

It may interest you: Cristiano Ronaldo, beautiful niece comes to light and the networks go crazy

Without a doubt, the track was altered at the moment that Loza revealed the evidence of his hard training on stage and with tremendous movements next to the Negra de Oro, which is why Andrea Legarreta He couldn’t hide his nervousness.

With a “I don’t know what I was going to tell them”, Galilea Montijo’s friend and colleague assured that she forgot her criticism after seeing how the handsome actor took off his shirt and soon filled Jorge Loza with compliments and then thanked him the hard work you are surely doing in the gym.

Legarreta confessed that she has known the celebrity from the reality show Guerreros 2020 and the difference in her anatomy from that reality show to today, which is part of Las Estrellas Bailan en Hoy, is evident.

The beauty of the actor definitely altered many, because even Emma Pulido, who acts as the Iron Judge, forgot this role and full of compliments to the handsome famous man, assuring that even she had a “joyful eye”.

Unfortunately, this broadcast of the reality show program today It has stood out more for the injuries and altercations that celebrities have had, especially in the rehearsals that are carried out in the forums.
Marie Claire, José Manuel Figueroa’s partner had to leave on an emergency stretcher after a heavy fall in a load; who has also shared ending up on the ground in rehearsals is the beautiful Lis Vega.

Follow us on

I have a degree in Nutrition from the Autonomous University of Durango. I began my career as a journalist at El Debate Mazatlán in March 2017, working on international stories for the debate.com.mx website. Subsequently, Grupo Debate began to focus on various regions of the country, so I wrote notes and managed the Debate Guadalajara Facebook page. Being a company in constant movement, I moved to general content writing and currently I work as Web Editor of the Show News vertical, which I have taken since its launch on June 8, 2019. Show News had an explosive start and ascent. In the time that I have developed in this great work team, I have been part of the constant renewal of El Debate, all with the aim of truthfully informing and adapting to the needs of both local and international followers.

see more

Andrea Legarreta, does your marriage falter?, flirts in full Today

The post Andrea Legarreta, does your marriage falter?, flirts in full Today first appeared on Fastmediaservice.

[date_timestamp] => 1656493987 ) [4] => Array ( [title] => We tell you everything: why these celebrities are part of the Ferrari blacklist [link] => https://fastmediaservice.com/we-tell-you-everything-why-these-celebrities-are-part-of-the-ferrari-blacklist/ [dc] => Array ( [creator] => Michael Steiner ) [pubdate] => Wed, 29 Jun 2022 08:54:19 +0000 [category] => Latest NewsblacklistcelebritiesFerraripart [guid] => https://fastmediaservice.com/?p=2167 [description] =>

The Italian sports car brand is very rigorous and has rules for people who buy their cars. They do it to take care of their image and whoever breaks the rules is banned from future purchases. There are several celebrities who are prohibited from getting models of the ‘Cavallino Rampante’ and here we explain why. ... Read more

The post We tell you everything: why these celebrities are part of the Ferrari blacklist first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

The Italian sports car brand is very rigorous and has rules for people who buy their cars. They do it to take care of their image and whoever breaks the rules is banned from future purchases. There are several celebrities who are prohibited from getting models of the ‘Cavallino Rampante’ and here we explain why.

If we talk about luxury cars, one of the first brands that comes to mind is Ferrari. With a long tradition in the automotive industry, it has forged a status within the market and that is why it has the luxury of imposing rules on its buyers to take care of the image of its powerful and powerful cars. Those who fail to comply with these regulations have been included in a ‘black list’ in which they are totally banned from buying Italian vehicles.

Celebrities who have been banned by Ferrari

5. Nicholas Cage

At the time, the actor made headlines when Ferrari decided not to sell him more of their cars. He bought the Enzo edition, valued at a million dollars. Although he paid for it, it seems that Nicolas Cage had a financial crisis and the first decision he made was to sell this car and he did it for a much lower value than the company stipulated. For that reason, he went straight to the Prancing Horse blacklist.

4. Deadmau5

In 2013, the most curious veto ever seen at Ferrari was given. This musician decided to stamp a ‘NyanCat’ on his Ferrari 458 Spider and renamed it ‘Purrari’. Well, many of his followers liked this customization, but the Italian company did not. Since then, Deadmau5 cannot buy any more cars of this brand.

3. 50 Cent

The famous rapper also had Ferrari cars in his garage, but on one occasion he decided to use his image to put pressure and publicly complain against the Italian firm. He bought the 488 edition, claimed that the car would not start and in the end it was revealed that the battery was dead. Just because of the controversy he created, Ferrari added him to his list of vetoes.

2.Kim Kardashian

One of the strongest policies that Ferrari has has to do with the purchase. Any business that can generate some kind of public scandal is frowned upon by the company. Well, Kim got one of the Italians from him through a dubious purchase with a financial scammer. For that reason, the leader of the Kardashians cannot even go near a Prancing Horse store.

1.Floyd Mayweather

If there is an extravagant figure in the world of sports, it is Mayweather. The absurd amount of money this man makes from his boxing matches almost makes no sense. Also, he spends his fortune buying luxury cars. Well, Ferrari wanted the popular ‘Money’ to have one of his machines, but the sportsman almost always decides to sell his cars later. The Italians considered that he would not value the brand and decided not to sell him a single vehicle.

We tell you everything: why these celebrities are part of the Ferrari blacklist

The post We tell you everything: why these celebrities are part of the Ferrari blacklist first appeared on Fastmediaservice.

) [summary] =>

The Italian sports car brand is very rigorous and has rules for people who buy their cars. They do it to take care of their image and whoever breaks the rules is banned from future purchases. There are several celebrities who are prohibited from getting models of the ‘Cavallino Rampante’ and here we explain why. ... Read more

The post We tell you everything: why these celebrities are part of the Ferrari blacklist first appeared on Fastmediaservice.

[atom_content] =>

The Italian sports car brand is very rigorous and has rules for people who buy their cars. They do it to take care of their image and whoever breaks the rules is banned from future purchases. There are several celebrities who are prohibited from getting models of the ‘Cavallino Rampante’ and here we explain why.

If we talk about luxury cars, one of the first brands that comes to mind is Ferrari. With a long tradition in the automotive industry, it has forged a status within the market and that is why it has the luxury of imposing rules on its buyers to take care of the image of its powerful and powerful cars. Those who fail to comply with these regulations have been included in a ‘black list’ in which they are totally banned from buying Italian vehicles.

Celebrities who have been banned by Ferrari

5. Nicholas Cage

At the time, the actor made headlines when Ferrari decided not to sell him more of their cars. He bought the Enzo edition, valued at a million dollars. Although he paid for it, it seems that Nicolas Cage had a financial crisis and the first decision he made was to sell this car and he did it for a much lower value than the company stipulated. For that reason, he went straight to the Prancing Horse blacklist.

4. Deadmau5

In 2013, the most curious veto ever seen at Ferrari was given. This musician decided to stamp a ‘NyanCat’ on his Ferrari 458 Spider and renamed it ‘Purrari’. Well, many of his followers liked this customization, but the Italian company did not. Since then, Deadmau5 cannot buy any more cars of this brand.

3. 50 Cent

The famous rapper also had Ferrari cars in his garage, but on one occasion he decided to use his image to put pressure and publicly complain against the Italian firm. He bought the 488 edition, claimed that the car would not start and in the end it was revealed that the battery was dead. Just because of the controversy he created, Ferrari added him to his list of vetoes.

2.Kim Kardashian

One of the strongest policies that Ferrari has has to do with the purchase. Any business that can generate some kind of public scandal is frowned upon by the company. Well, Kim got one of the Italians from him through a dubious purchase with a financial scammer. For that reason, the leader of the Kardashians cannot even go near a Prancing Horse store.

1.Floyd Mayweather

If there is an extravagant figure in the world of sports, it is Mayweather. The absurd amount of money this man makes from his boxing matches almost makes no sense. Also, he spends his fortune buying luxury cars. Well, Ferrari wanted the popular ‘Money’ to have one of his machines, but the sportsman almost always decides to sell his cars later. The Italians considered that he would not value the brand and decided not to sell him a single vehicle.

We tell you everything: why these celebrities are part of the Ferrari blacklist

The post We tell you everything: why these celebrities are part of the Ferrari blacklist first appeared on Fastmediaservice.

[date_timestamp] => 1656492859 ) [5] => Array ( [title] => Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data [link] => https://fastmediaservice.com/volunteer-neighborhood-scientists-do-a-pretty-darn-good-job-generating-usable-data/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 08:03:16 +0000 [category] => sciencedarndatageneratinggoodjobneighborhoodprettyScientistsusableVolunteer [guid] => https://fastmediaservice.com/?p=2165 [description] =>

Journal Reference: Melanie Pivarski, Matt von Konrat, Thomas Campbell, Ayesha Qazi-Lampert, Laura Trouille, Heaven Wade, Aimee Davis, Selma Aburahmeh, Joseph Aguilar, Cosmin Alb, Ken Alferes, Ella Barker, Karl Bitikofer, Kelli Boulware, Carla Bruton, Sicong Cao, Arturo Corona Jr., Christine Christian, Kaltra Demiri, Daniel Evans, Nkosi Evans, Connor Flavin, Jasmine Gillis, Victoria Gogol, Elizabeth Heublein, Edward ... Read more

The post Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Melanie Pivarski, Matt von Konrat, Thomas Campbell, Ayesha Qazi-Lampert, Laura Trouille, Heaven Wade, Aimee Davis, Selma Aburahmeh, Joseph Aguilar, Cosmin Alb, Ken Alferes, Ella Barker, Karl Bitikofer, Kelli Boulware, Carla Bruton, Sicong Cao, Arturo Corona Jr., Christine Christian, Kaltra Demiri, Daniel Evans, Nkosi Evans, Connor Flavin, Jasmine Gillis, Victoria Gogol, Elizabeth Heublein, Edward Huang, Jake Hutchinson, Cyrus Jackson, Odaliz Jackson, Lauren Johnson, Michi Kirihara, Henry Kivarkis, Annette Kowalczyk, Alex Labontu, Briajia Levi, Ian Lyu, Sylvie Martin-Eberhardt, Gaby Mata, Joann Martinec, Beth McDonald, Mariola Mira, Minh Nguyen, Pansy Nguyen, Sarah Nolimal, Victoria Reese, Will Ritchie, Joannie Rodriguez, Yarency Rodriguez, Jacob Shuler, Jasmine Silvestre, Glenn Simpson, Gabriel Somarriba, Rogers Ssozi, Tomomi Suwa, Cheyenne Syring, Nidhi Thirthamattur, Keith Thompson, Caitlin Vaughn, Mario Viramontes, Chak Shing Wong, Lauren Wszolek. People-Powered Research and Experiential Learning: Unravelling Hidden Biodiversity. Research Ideas and Outcomes, 2022; 8 DOI: 10.3897/rio.8.e83853

?It was surprising how all age groups from young children, families, youth, and adults were able to generate high-quality taxonomic data sets, making observations and preparing measurements, and at the same time empowering community scientists through authentic contributions to science,? says Matt von Konrat, an author of the paper in the journal Research Ideas and Outcomes and the head of plant collections at Chicago?s Field Museum.

?This study demonstrates the wonderful scientific outcomes that occur when an entire community comes together,? says Melanie Pivarski, an associate professor of mathematics at Roosevelt University and the study?s lead author. ?We were able to combine a small piece of the Field Museum?s vast collections, their scientific knowledge and exhibit creation expertise, the observational skills of biology interns at Northeastern Illinois University led by our collaborator Tom Campbell, and our Roosevelt University student?s data science expertise. The creation of this set of high-quality data was a true community effort!?

The study focuses on an activity in an exhibition at the Field Museum, in which visitors could partake in a community science project. (Community science is sometimes called citizen science, but since not everyone is a citizen, community science is a more inclusive name.) In the community science activity, museumgoers used a large digital touchscreen to measure the microscopic leaves photographs of plants called liverworts.

These tiny plants, the size of an eyelash, are sensitive to climate change, and they can act like a canary in a coal mine to let scientists know about how climate change is affecting a region. It?s helpful for scientists to know what kinds of liverworts are present in an area, but since the plants are so tiny, it?s hard to tell them apart. The sizes of their leaves (or rather, lobes ? these are some of the most ancient land plants on Earth, and they evolved before true leaves had formed) can hint at their species. But it would take ages for any one scientist to measure all the leaves of the specimens in the Field?s collection. Enter the community scientists.

?Drawing a fine line to measure the lobe of a liverwort for a few hours can be mentally strenuous, so it?s great to have community scientists take a few minutes out of their day using fresh eyes to help measure a plant leaf. A few community scientists who?ve helped with classifying acknowledged how exciting it is knowing they are playing a helping hand in scientific discovery,?says Heaven Wade, a research assistant at the Field Museum who began working on the MicroPlants project as an undergraduate intern.

Community scientists using the digital platform measured thousands of microscopic liverwort leaves over the course of two years.

?At the beginning, we needed to find a way to sort the high quality measurements out from the rest. We didn?t know if there would be kids drawing pictures on the touchscreen instead of measuring leaves or if they?d be able to follow the tutorial as well as the adults did. We also needed to be able to automate a method to determine the accuracy of these higher quality measurements,? says Pivarski.

To answer these questions, Pivarski worked with her students at Roosevelt University to analyze the data. They compared measurements taken by the community scientists with measurements done by experts on a couple ?test? lobes; based on that proof of concept, they went on to analyze the thousands of other leaf measurements. The results were surprising.

?We were amazed at how wonderfully children did at this task; it was counter to our initial expectations. The majority of measurements were high quality. This allowed my students to create an automated process that produced an accurate set of MicroPlant measurements from the larger dataset,? says Pivarski.

The researchers say that the study supports the argument that community science is valuable not just as a teaching tool to get people interested in science, but as a valid means of data collection.

?Biological collections are uniquely poised to inform the stewardship of life on Earth in a time of cataclysmic biodiversity loss, yet efforts to fully leverage collections are impeded by a lack of trained taxonomists. Crowd-sourced data collection projects like these have the potential to greatly accelerate biodiversity discovery and documentation from digital images of scientific specimens,? says von Konrat.

Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data

The post Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Melanie Pivarski, Matt von Konrat, Thomas Campbell, Ayesha Qazi-Lampert, Laura Trouille, Heaven Wade, Aimee Davis, Selma Aburahmeh, Joseph Aguilar, Cosmin Alb, Ken Alferes, Ella Barker, Karl Bitikofer, Kelli Boulware, Carla Bruton, Sicong Cao, Arturo Corona Jr., Christine Christian, Kaltra Demiri, Daniel Evans, Nkosi Evans, Connor Flavin, Jasmine Gillis, Victoria Gogol, Elizabeth Heublein, Edward ... Read more

The post Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Melanie Pivarski, Matt von Konrat, Thomas Campbell, Ayesha Qazi-Lampert, Laura Trouille, Heaven Wade, Aimee Davis, Selma Aburahmeh, Joseph Aguilar, Cosmin Alb, Ken Alferes, Ella Barker, Karl Bitikofer, Kelli Boulware, Carla Bruton, Sicong Cao, Arturo Corona Jr., Christine Christian, Kaltra Demiri, Daniel Evans, Nkosi Evans, Connor Flavin, Jasmine Gillis, Victoria Gogol, Elizabeth Heublein, Edward Huang, Jake Hutchinson, Cyrus Jackson, Odaliz Jackson, Lauren Johnson, Michi Kirihara, Henry Kivarkis, Annette Kowalczyk, Alex Labontu, Briajia Levi, Ian Lyu, Sylvie Martin-Eberhardt, Gaby Mata, Joann Martinec, Beth McDonald, Mariola Mira, Minh Nguyen, Pansy Nguyen, Sarah Nolimal, Victoria Reese, Will Ritchie, Joannie Rodriguez, Yarency Rodriguez, Jacob Shuler, Jasmine Silvestre, Glenn Simpson, Gabriel Somarriba, Rogers Ssozi, Tomomi Suwa, Cheyenne Syring, Nidhi Thirthamattur, Keith Thompson, Caitlin Vaughn, Mario Viramontes, Chak Shing Wong, Lauren Wszolek. People-Powered Research and Experiential Learning: Unravelling Hidden Biodiversity. Research Ideas and Outcomes, 2022; 8 DOI: 10.3897/rio.8.e83853

?It was surprising how all age groups from young children, families, youth, and adults were able to generate high-quality taxonomic data sets, making observations and preparing measurements, and at the same time empowering community scientists through authentic contributions to science,? says Matt von Konrat, an author of the paper in the journal Research Ideas and Outcomes and the head of plant collections at Chicago?s Field Museum.

?This study demonstrates the wonderful scientific outcomes that occur when an entire community comes together,? says Melanie Pivarski, an associate professor of mathematics at Roosevelt University and the study?s lead author. ?We were able to combine a small piece of the Field Museum?s vast collections, their scientific knowledge and exhibit creation expertise, the observational skills of biology interns at Northeastern Illinois University led by our collaborator Tom Campbell, and our Roosevelt University student?s data science expertise. The creation of this set of high-quality data was a true community effort!?

The study focuses on an activity in an exhibition at the Field Museum, in which visitors could partake in a community science project. (Community science is sometimes called citizen science, but since not everyone is a citizen, community science is a more inclusive name.) In the community science activity, museumgoers used a large digital touchscreen to measure the microscopic leaves photographs of plants called liverworts.

These tiny plants, the size of an eyelash, are sensitive to climate change, and they can act like a canary in a coal mine to let scientists know about how climate change is affecting a region. It?s helpful for scientists to know what kinds of liverworts are present in an area, but since the plants are so tiny, it?s hard to tell them apart. The sizes of their leaves (or rather, lobes ? these are some of the most ancient land plants on Earth, and they evolved before true leaves had formed) can hint at their species. But it would take ages for any one scientist to measure all the leaves of the specimens in the Field?s collection. Enter the community scientists.

?Drawing a fine line to measure the lobe of a liverwort for a few hours can be mentally strenuous, so it?s great to have community scientists take a few minutes out of their day using fresh eyes to help measure a plant leaf. A few community scientists who?ve helped with classifying acknowledged how exciting it is knowing they are playing a helping hand in scientific discovery,?says Heaven Wade, a research assistant at the Field Museum who began working on the MicroPlants project as an undergraduate intern.

Community scientists using the digital platform measured thousands of microscopic liverwort leaves over the course of two years.

?At the beginning, we needed to find a way to sort the high quality measurements out from the rest. We didn?t know if there would be kids drawing pictures on the touchscreen instead of measuring leaves or if they?d be able to follow the tutorial as well as the adults did. We also needed to be able to automate a method to determine the accuracy of these higher quality measurements,? says Pivarski.

To answer these questions, Pivarski worked with her students at Roosevelt University to analyze the data. They compared measurements taken by the community scientists with measurements done by experts on a couple ?test? lobes; based on that proof of concept, they went on to analyze the thousands of other leaf measurements. The results were surprising.

?We were amazed at how wonderfully children did at this task; it was counter to our initial expectations. The majority of measurements were high quality. This allowed my students to create an automated process that produced an accurate set of MicroPlant measurements from the larger dataset,? says Pivarski.

The researchers say that the study supports the argument that community science is valuable not just as a teaching tool to get people interested in science, but as a valid means of data collection.

?Biological collections are uniquely poised to inform the stewardship of life on Earth in a time of cataclysmic biodiversity loss, yet efforts to fully leverage collections are impeded by a lack of trained taxonomists. Crowd-sourced data collection projects like these have the potential to greatly accelerate biodiversity discovery and documentation from digital images of scientific specimens,? says von Konrat.

Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data

The post Volunteer ?neighborhood scientists? do a pretty darn good job generating usable data first appeared on Fastmediaservice.

[date_timestamp] => 1656489796 ) [6] => Array ( [title] => Maternal mortality jumped during COVID-19 pandemic [link] => https://fastmediaservice.com/maternal-mortality-jumped-during-covid-19-pandemic/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 06:42:57 +0000 [category] => scienceCOVID19jumpedMaternalmortalitypandemic [guid] => https://fastmediaservice.com/?p=2163 [description] =>

Journal Reference: Marie E. Thoma, Eugene R. Declercq. All-Cause Maternal Mortality in the US Before vs During the COVID-19 Pandemic. JAMA Network Open, 2022; 5 (6): e2219133 DOI: 10.1001/jamanetworkopen.2022.19133 A research letter published in JAMA Network Open by Marie Thoma in the UMD School of Public Health and Eugene Declercq in the BU School of ... Read more

The post Maternal mortality jumped during COVID-19 pandemic first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Marie E. Thoma, Eugene R. Declercq. All-Cause Maternal Mortality in the US Before vs During the COVID-19 Pandemic. JAMA Network Open, 2022; 5 (6): e2219133 DOI: 10.1001/jamanetworkopen.2022.19133

A research letter published in JAMA Network Open by Marie Thoma in the UMD School of Public Health and Eugene Declercq in the BU School of Public Health compared maternal mortality data from 2018-March 2020, when the pandemic began, to April-December 2020. Overall, they found large increases in maternal death (33%) and late maternal deaths (41%) after March 2020 compared with before the pandemic, and conspicuous increases among Black and Hispanic mothers.

?The increase was really driven by deaths after the start of the pandemic, which are higher than what we see for overall excess mortality in 2020,? said Dr. Thoma, assistant professor of family science in the UMD SPH. The study also showed that existing and new disparities emerged after the pandemic with a 40% jump among already high rates for non-Hispanic Black women and a 74% jump among formerly lower rates in Hispanic women.

Strikingly, said Dr. Declercq, professor of community health sciences at BUSPH, ?for the first time in more than a decade, the maternal mortality rate for Hispanic women during the pandemic was higher than that for non-Hispanic white women, a shift that may be related to COVID and deserves greater attention moving forward.?

COVID-19 was listed as a secondary cause of death in 14.9% of maternal deaths in the last nine months of 2020, with it being a contributing factor for 32% of Hispanic, 12.9% of Black and 7% of non-Hispanic white women giving birth.

In their analysis of causes of maternal death, they found the largest increases were due to conditions directly related to COVID-19 (respiratory or viral infection) and conditions made worse by COVID-19 infection, such as diabetes or cardiovascular disease. However, interruptions to the health care system could have led to delayed prenatal care that could have meant that risk factors for pregnancy complications went undetected.

?We need more detailed data on the specific causes of maternal deaths overall and those associated with COVID-19,? Dr. Thoma said. ?Potentially we could see improvements in 2021 due to the rollout of vaccines, as well as the extension of postpartum care provided for Medicaid recipients as part of the American Rescue Act of 2021 in some states. We?re going to continue to examine this.?

Maternal mortality jumped during COVID-19 pandemic

The post Maternal mortality jumped during COVID-19 pandemic first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Marie E. Thoma, Eugene R. Declercq. All-Cause Maternal Mortality in the US Before vs During the COVID-19 Pandemic. JAMA Network Open, 2022; 5 (6): e2219133 DOI: 10.1001/jamanetworkopen.2022.19133 A research letter published in JAMA Network Open by Marie Thoma in the UMD School of Public Health and Eugene Declercq in the BU School of ... Read more

The post Maternal mortality jumped during COVID-19 pandemic first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Marie E. Thoma, Eugene R. Declercq. All-Cause Maternal Mortality in the US Before vs During the COVID-19 Pandemic. JAMA Network Open, 2022; 5 (6): e2219133 DOI: 10.1001/jamanetworkopen.2022.19133

A research letter published in JAMA Network Open by Marie Thoma in the UMD School of Public Health and Eugene Declercq in the BU School of Public Health compared maternal mortality data from 2018-March 2020, when the pandemic began, to April-December 2020. Overall, they found large increases in maternal death (33%) and late maternal deaths (41%) after March 2020 compared with before the pandemic, and conspicuous increases among Black and Hispanic mothers.

?The increase was really driven by deaths after the start of the pandemic, which are higher than what we see for overall excess mortality in 2020,? said Dr. Thoma, assistant professor of family science in the UMD SPH. The study also showed that existing and new disparities emerged after the pandemic with a 40% jump among already high rates for non-Hispanic Black women and a 74% jump among formerly lower rates in Hispanic women.

Strikingly, said Dr. Declercq, professor of community health sciences at BUSPH, ?for the first time in more than a decade, the maternal mortality rate for Hispanic women during the pandemic was higher than that for non-Hispanic white women, a shift that may be related to COVID and deserves greater attention moving forward.?

COVID-19 was listed as a secondary cause of death in 14.9% of maternal deaths in the last nine months of 2020, with it being a contributing factor for 32% of Hispanic, 12.9% of Black and 7% of non-Hispanic white women giving birth.

In their analysis of causes of maternal death, they found the largest increases were due to conditions directly related to COVID-19 (respiratory or viral infection) and conditions made worse by COVID-19 infection, such as diabetes or cardiovascular disease. However, interruptions to the health care system could have led to delayed prenatal care that could have meant that risk factors for pregnancy complications went undetected.

?We need more detailed data on the specific causes of maternal deaths overall and those associated with COVID-19,? Dr. Thoma said. ?Potentially we could see improvements in 2021 due to the rollout of vaccines, as well as the extension of postpartum care provided for Medicaid recipients as part of the American Rescue Act of 2021 in some states. We?re going to continue to examine this.?

Maternal mortality jumped during COVID-19 pandemic

The post Maternal mortality jumped during COVID-19 pandemic first appeared on Fastmediaservice.

[date_timestamp] => 1656484977 ) [7] => Array ( [title] => Strategies beyond recycling to bolster circular economy for solar and battery technologies [link] => https://fastmediaservice.com/strategies-beyond-recycling-to-bolster-circular-economy-for-solar-and-battery-technologies/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 05:22:57 +0000 [category] => sciencebatterybolstercirculareconomyrecyclingSolarStrategiestechnologies [guid] => https://fastmediaservice.com/?p=2161 [description] =>

Journal Reference: Garvin A. Heath, Dwarakanath Ravikumar, Brianna Hansen, Elaine Kupets. A critical review of the circular economy for lithium-ion batteries and photovoltaic modules ? status, challenges, and opportunities. Journal of the Air & Waste Management Association, 2022; 72 (6): 478 DOI: 10.1080/10962247.2022.2068878 These insights come after an analysis of more than 3,000 scientific publications ... Read more

The post Strategies beyond recycling to bolster circular economy for solar and battery technologies first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Garvin A. Heath, Dwarakanath Ravikumar, Brianna Hansen, Elaine Kupets. A critical review of the circular economy for lithium-ion batteries and photovoltaic modules ? status, challenges, and opportunities. Journal of the Air & Waste Management Association, 2022; 72 (6): 478 DOI: 10.1080/10962247.2022.2068878

These insights come after an analysis of more than 3,000 scientific publications exploring the life cycle of the most common PV and lithium-ion battery technologies, including starting materials, environmental impacts, and end-of-life options. The NREL researchers examined 10 possible pathways toward a circular economy. The findings highlight key insights, gaps, and opportunities for research and implementation of a circular economy for PV and battery technologies, including strategies that are currently being underutilized.

Demand for PV panels and lithium-ion batteries is expected to increase as the United States shifts away from fossil fuels and deploys more clean energy. Creating a robust circular economy for these technologies could mitigate demand for starting materials and reduce waste and environmental impacts. Circular economy strategies also have the potential to create clean energy jobs and address environmental justice concerns.

The researchers noted the emphasis on recycling may overlook the challenges and opportunities that research into other strategies could reveal. ?If you can keep them as a working product for longer, that?s better than deconstructing it all the way down to the elements that occurs during recycling,? said Garvin Heath, senior environmental scientist and energy analyst and Distinguished Member of Research Staff at NREL. ?And when a product does reach the end of its life, recycling is not the only option.?

The deconstruction process takes more energy and generates more associated greenhouse gas emissions to then build into another product than keeping the first product in use longer, he said. Heath, along with his NREL colleague Dwarakanath Ravikumar, are lead authors of the 52nd annual Critical Review of the Air & Waste Management Association, titled ?A Critical Review of Circular Economy for Lithium-Ion Batteries and Photovoltaic Modules ? Status, Challenges, and Opportunities,? which appears in the June edition of the Journal of the Air & Waste Management Association.

Their co-authors, also from NREL, are Brianna Hansen and Elaine Kupets.

?People often summarize the product life cycle as ?take, make, waste.’? Heath said. ?Recycling has received a lot of attention because it addresses the waste part, but there are ways to support a circular economy in the take part and the make part, too.?

Recycling to recover the materials used in the technologies is preferable to discarding them in a landfill, he said, ?but if we can think about designing a product to use less materials to begin with, or less hazardous materials, that should be the first strategy.?

The authors also noted that challenges remain in developing PV and battery recycling methods. There are currently no integrated recycling processes that can recover all the materials for either technology, and existing research has focused more on lab-scale methods.

NREL is already leading efforts to improve PV reliability, extend PV life spans, reduce the use of hazardous materials, and decrease demand for starting materials. This includes leading the Durable Module Materials Consortium (DuraMAT), which is researching ways to extend the useful life of PV modules, and the Bio-Optimized Technologies to keep Thermoplastics out of Landfills and the Environment (BOTTLE) Consortium, which is developing ways to improve the recycling of plastics.

NREL is also a partner in the Argonne National Laboratory-led consortium ReCell, which works with industry, academia, and national laboratories to advance recycling technologies along the entire battery life cycle for current and future battery chemistries.

The U.S. Department of Energy?s Advanced Manufacturing Office and Solar Energy Technologies Office funded the research.

Strategies beyond recycling to bolster circular economy for solar and battery technologies

The post Strategies beyond recycling to bolster circular economy for solar and battery technologies first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Garvin A. Heath, Dwarakanath Ravikumar, Brianna Hansen, Elaine Kupets. A critical review of the circular economy for lithium-ion batteries and photovoltaic modules ? status, challenges, and opportunities. Journal of the Air & Waste Management Association, 2022; 72 (6): 478 DOI: 10.1080/10962247.2022.2068878 These insights come after an analysis of more than 3,000 scientific publications ... Read more

The post Strategies beyond recycling to bolster circular economy for solar and battery technologies first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Garvin A. Heath, Dwarakanath Ravikumar, Brianna Hansen, Elaine Kupets. A critical review of the circular economy for lithium-ion batteries and photovoltaic modules ? status, challenges, and opportunities. Journal of the Air & Waste Management Association, 2022; 72 (6): 478 DOI: 10.1080/10962247.2022.2068878

These insights come after an analysis of more than 3,000 scientific publications exploring the life cycle of the most common PV and lithium-ion battery technologies, including starting materials, environmental impacts, and end-of-life options. The NREL researchers examined 10 possible pathways toward a circular economy. The findings highlight key insights, gaps, and opportunities for research and implementation of a circular economy for PV and battery technologies, including strategies that are currently being underutilized.

Demand for PV panels and lithium-ion batteries is expected to increase as the United States shifts away from fossil fuels and deploys more clean energy. Creating a robust circular economy for these technologies could mitigate demand for starting materials and reduce waste and environmental impacts. Circular economy strategies also have the potential to create clean energy jobs and address environmental justice concerns.

The researchers noted the emphasis on recycling may overlook the challenges and opportunities that research into other strategies could reveal. ?If you can keep them as a working product for longer, that?s better than deconstructing it all the way down to the elements that occurs during recycling,? said Garvin Heath, senior environmental scientist and energy analyst and Distinguished Member of Research Staff at NREL. ?And when a product does reach the end of its life, recycling is not the only option.?

The deconstruction process takes more energy and generates more associated greenhouse gas emissions to then build into another product than keeping the first product in use longer, he said. Heath, along with his NREL colleague Dwarakanath Ravikumar, are lead authors of the 52nd annual Critical Review of the Air & Waste Management Association, titled ?A Critical Review of Circular Economy for Lithium-Ion Batteries and Photovoltaic Modules ? Status, Challenges, and Opportunities,? which appears in the June edition of the Journal of the Air & Waste Management Association.

Their co-authors, also from NREL, are Brianna Hansen and Elaine Kupets.

?People often summarize the product life cycle as ?take, make, waste.’? Heath said. ?Recycling has received a lot of attention because it addresses the waste part, but there are ways to support a circular economy in the take part and the make part, too.?

Recycling to recover the materials used in the technologies is preferable to discarding them in a landfill, he said, ?but if we can think about designing a product to use less materials to begin with, or less hazardous materials, that should be the first strategy.?

The authors also noted that challenges remain in developing PV and battery recycling methods. There are currently no integrated recycling processes that can recover all the materials for either technology, and existing research has focused more on lab-scale methods.

NREL is already leading efforts to improve PV reliability, extend PV life spans, reduce the use of hazardous materials, and decrease demand for starting materials. This includes leading the Durable Module Materials Consortium (DuraMAT), which is researching ways to extend the useful life of PV modules, and the Bio-Optimized Technologies to keep Thermoplastics out of Landfills and the Environment (BOTTLE) Consortium, which is developing ways to improve the recycling of plastics.

NREL is also a partner in the Argonne National Laboratory-led consortium ReCell, which works with industry, academia, and national laboratories to advance recycling technologies along the entire battery life cycle for current and future battery chemistries.

The U.S. Department of Energy?s Advanced Manufacturing Office and Solar Energy Technologies Office funded the research.

Strategies beyond recycling to bolster circular economy for solar and battery technologies

The post Strategies beyond recycling to bolster circular economy for solar and battery technologies first appeared on Fastmediaservice.

[date_timestamp] => 1656480177 ) [8] => Array ( [title] => Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats [link] => https://fastmediaservice.com/scientists-identify-new-brain-mechanism-involved-in-impulsive-cocaine-seeking-in-rats/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 04:03:10 +0000 [category] => sciencebraincocaineseekingidentifyimpulsiveinvolvedmechanismratsScientists [guid] => https://fastmediaservice.com/?p=2159 [description] =>

Journal Reference: Clara I.C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman and Carl R. Lupica. Muscarinic Acetylcholine M2 Receptors Regulate Lateral Habenula Neuron Activity and Control Cocaine Seeking Behavior. Journal of Neuroscience, 2022 DOI: 10.1523/JNEUROSCI.0645-22.2022 Published in the Journal of Neuroscience, the study was supported by the National Institute on Drug ... Read more

The post Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Clara I.C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman and Carl R. Lupica. Muscarinic Acetylcholine M2 Receptors Regulate Lateral Habenula Neuron Activity and Control Cocaine Seeking Behavior. Journal of Neuroscience, 2022 DOI: 10.1523/JNEUROSCI.0645-22.2022

Published in the Journal of Neuroscience, the study was supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. In 2020, over 41,000 people died from drug overdoses involving stimulants, including cocaine and methamphetamine. Developing safe and effective medications that help treat addictions to cocaine and other stimulants is critical to expand the choices offered to people seeking treatment and to help sustain recovery.

?This discovery gives researchers a new, specific target toward solving a problem that has long been elusive ? developing treatments for cocaine addiction,? said NIDA Director, Nora Volkow, M.D. ?As we have seen with medications to treat opioid use disorder, adding this tool to clinical care could save lives from overdose and drastically improve health and quality of life.?

Addiction science researchers are particularly interested in the LHb as a target for future treatment development because of its position as an interface between brain regions involved with reasoning and other higher order thought processes and those mediating emotion and reward ? factors known to be associated with substance use disorders as well as major depressive disorders. For instance, these areas are involved in regulating behaviors like abstaining from a reward when it is determined not to be ?beneficial.?

Building on previous work that established the importance of the LHb and acetylcholine receptor signaling in impulsive cocaine-seeking, this study further defines the cellular mechanisms through which LHb neurons regulate this behavior. Researchers used a behavioral paradigm called the Go/NoGo model in rats. In this model, rats were trained to self-administer cocaine, where a lever press led to an injection of the drug. This was followed by specific training in the Go/NoGo task where cocaine was available when the lights were on (Go), but not when the lights were off (NoGo). Animals quickly learned to stop responding when cocaine was not available.

The researchers then chemically manipulated the LHb, to assess the impact on the rats? ability to withhold their response to cocaine. They found that response inhibition for cocaine was impaired by blocking a specific type of muscarinic acetylcholine receptor, known as M2Rs, with an experimental drug called AFDX-116, and not with a drug called pirenzepine that blocks other muscarinic acetylcholine receptors known as M1Rs. Thus, when M2Rs were blocked in the LHb the rodents were no longer able to stop responding for cocaine even when it was not available (the ?NoGo? condition), despite the training. This indicates that increasing LHb M2R function may represent a potential target for treating impulsive drug seeking and substance use disorders.

The researchers also studied the cellular mechanisms by which M2Rs alter LHb neuronal activity by measuring changes in the electrical activity of these neurons in response to acetylcholine-like drugs. Although these drugs reduced both excitatory and inhibitory inputs onto LHb neurons, there was a net increase in inhibition, which may account for acetylcholine?s ability to limit impulsive cocaine seeking.

?The LHb acts like an interface between rational thought in the forebrain and the modulation of neurotransmitters like dopamine and serotonin that originate in the midbrain, which are important in regulating decision processes and emotions,? said Carl Lupica, Ph.D., chief of the Electrophysiology Research Section of the Computational and Systems Neuroscience Branch of NIDA. ?While the immediate results of this study are related to cocaine seeking, there are also greater implications for impulsivity as it relates to other drugs as well as to psychiatric conditions like obsessive-compulsive disorder. Our future studies will explore the relationship between LHb activity and impulsive behavior related to other drugs such as cannabis, and opioids such as heroin.?

Although targeting M2Rs is promising, there are challenges because the muscarinic acetylcholine system is involved in everything from regulating heart rate, affecting motion sickness, and controlling vasodilation, for example. These receptors are also located throughout the body, including many other regions of the brain. Further research is needed to develop ways to target the M2Rs in the LHb without causing a cascade of side effects, and as a first step these researchers are now trying to identify where in the brain the acetylcholine released in the LHb originates.

The study was funded by the NIDA Intramural Research Program.

Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats

The post Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Clara I.C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman and Carl R. Lupica. Muscarinic Acetylcholine M2 Receptors Regulate Lateral Habenula Neuron Activity and Control Cocaine Seeking Behavior. Journal of Neuroscience, 2022 DOI: 10.1523/JNEUROSCI.0645-22.2022 Published in the Journal of Neuroscience, the study was supported by the National Institute on Drug ... Read more

The post Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Clara I.C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman and Carl R. Lupica. Muscarinic Acetylcholine M2 Receptors Regulate Lateral Habenula Neuron Activity and Control Cocaine Seeking Behavior. Journal of Neuroscience, 2022 DOI: 10.1523/JNEUROSCI.0645-22.2022

Published in the Journal of Neuroscience, the study was supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. In 2020, over 41,000 people died from drug overdoses involving stimulants, including cocaine and methamphetamine. Developing safe and effective medications that help treat addictions to cocaine and other stimulants is critical to expand the choices offered to people seeking treatment and to help sustain recovery.

?This discovery gives researchers a new, specific target toward solving a problem that has long been elusive ? developing treatments for cocaine addiction,? said NIDA Director, Nora Volkow, M.D. ?As we have seen with medications to treat opioid use disorder, adding this tool to clinical care could save lives from overdose and drastically improve health and quality of life.?

Addiction science researchers are particularly interested in the LHb as a target for future treatment development because of its position as an interface between brain regions involved with reasoning and other higher order thought processes and those mediating emotion and reward ? factors known to be associated with substance use disorders as well as major depressive disorders. For instance, these areas are involved in regulating behaviors like abstaining from a reward when it is determined not to be ?beneficial.?

Building on previous work that established the importance of the LHb and acetylcholine receptor signaling in impulsive cocaine-seeking, this study further defines the cellular mechanisms through which LHb neurons regulate this behavior. Researchers used a behavioral paradigm called the Go/NoGo model in rats. In this model, rats were trained to self-administer cocaine, where a lever press led to an injection of the drug. This was followed by specific training in the Go/NoGo task where cocaine was available when the lights were on (Go), but not when the lights were off (NoGo). Animals quickly learned to stop responding when cocaine was not available.

The researchers then chemically manipulated the LHb, to assess the impact on the rats? ability to withhold their response to cocaine. They found that response inhibition for cocaine was impaired by blocking a specific type of muscarinic acetylcholine receptor, known as M2Rs, with an experimental drug called AFDX-116, and not with a drug called pirenzepine that blocks other muscarinic acetylcholine receptors known as M1Rs. Thus, when M2Rs were blocked in the LHb the rodents were no longer able to stop responding for cocaine even when it was not available (the ?NoGo? condition), despite the training. This indicates that increasing LHb M2R function may represent a potential target for treating impulsive drug seeking and substance use disorders.

The researchers also studied the cellular mechanisms by which M2Rs alter LHb neuronal activity by measuring changes in the electrical activity of these neurons in response to acetylcholine-like drugs. Although these drugs reduced both excitatory and inhibitory inputs onto LHb neurons, there was a net increase in inhibition, which may account for acetylcholine?s ability to limit impulsive cocaine seeking.

?The LHb acts like an interface between rational thought in the forebrain and the modulation of neurotransmitters like dopamine and serotonin that originate in the midbrain, which are important in regulating decision processes and emotions,? said Carl Lupica, Ph.D., chief of the Electrophysiology Research Section of the Computational and Systems Neuroscience Branch of NIDA. ?While the immediate results of this study are related to cocaine seeking, there are also greater implications for impulsivity as it relates to other drugs as well as to psychiatric conditions like obsessive-compulsive disorder. Our future studies will explore the relationship between LHb activity and impulsive behavior related to other drugs such as cannabis, and opioids such as heroin.?

Although targeting M2Rs is promising, there are challenges because the muscarinic acetylcholine system is involved in everything from regulating heart rate, affecting motion sickness, and controlling vasodilation, for example. These receptors are also located throughout the body, including many other regions of the brain. Further research is needed to develop ways to target the M2Rs in the LHb without causing a cascade of side effects, and as a first step these researchers are now trying to identify where in the brain the acetylcholine released in the LHb originates.

The study was funded by the NIDA Intramural Research Program.

Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats

The post Scientists identify new brain mechanism involved in impulsive cocaine-seeking in rats first appeared on Fastmediaservice.

[date_timestamp] => 1656475390 ) [9] => Array ( [title] => Many pain medications can be used for spine-related pain in older adults [link] => https://fastmediaservice.com/many-pain-medications-can-be-used-for-spine-related-pain-in-older-adults/ [dc] => Array ( [creator] => Michael Cowan ) [pubdate] => Wed, 29 Jun 2022 02:42:12 +0000 [category] => scienceAdultsmedicationsolderpainspinerelated [guid] => https://fastmediaservice.com/?p=2157 [description] =>

Journal Reference: Jonathan L. Fu, Michael D. Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & Aging, 2022; DOI: 10.1007/s40266-022-00946-x Now a new review study has found acetaminophen is safe in older adults, but non-steroidal anti-inflammatories (ibuprofen) may be more effective for spine-related pain. Non-steroidal anti-inflammatories should be used short-term in lower dose courses ... Read more

The post Many pain medications can be used for spine-related pain in older adults first appeared on Fastmediaservice.

[content] => Array ( [encoded] =>

Journal Reference:

  1. Jonathan L. Fu, Michael D. Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & Aging, 2022; DOI: 10.1007/s40266-022-00946-x

Now a new review study has found acetaminophen is safe in older adults, but non-steroidal anti-inflammatories (ibuprofen) may be more effective for spine-related pain. Non-steroidal anti-inflammatories should be used short-term in lower dose courses with gastrointestinal precaution while corticosteroids show the least evidence for treating nonspecific back pain.

Additionally, nerve pain medications (gabapentin and pregabalin) can be used in older persons, with caution to dose and kidney function. Newer antidepressants (duloxetine) more so than older ones (nortriptyline) can help with spine-related pain, with attention to possible sedation and dizziness. Some muscle relaxants (baclofen and tizanidine) can be used in older persons, again accounting for kidney and liver function. Opioids have limited use in common spine-related pain, but can be used with caution in cases that don?t respond to treatment.

?Most older people experience neck or low back pain at some point, bothersome enough to see their doctor. Our findings provide a helpful medication guide for physicians to use for spine pain in an older population that can have a complex medical history,? explained corresponding author Michael D. Perloff, MD, PhD, assistant professor of neurology at Boston University School of Medicine (BUSM) and a neurologist at Boston Medical Center.

The researchers performed a literature review to assess the evidence-basis for medications used for spine-related pain in older adults, with a focus on drug metabolism and adverse drug reactions. They then provided their recommendations based on safe and effective dosing.

Among their findings:

According to the researchers, complementary medicine, physical therapy, injections and surgery all have a place to help older persons with spine-related pain. ?Medications used at the correct dose, for the correct diagnosis, adjusting for preexisting medical problems can result in better use of treatments for spine pain,? added first author Jonathan Fu, a 2022 MD graduate from BUSM.

These findings appear online in the journal Drugs & Aging.

Many pain medications can be used for spine-related pain in older adults

The post Many pain medications can be used for spine-related pain in older adults first appeared on Fastmediaservice.

) [summary] =>

Journal Reference: Jonathan L. Fu, Michael D. Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & Aging, 2022; DOI: 10.1007/s40266-022-00946-x Now a new review study has found acetaminophen is safe in older adults, but non-steroidal anti-inflammatories (ibuprofen) may be more effective for spine-related pain. Non-steroidal anti-inflammatories should be used short-term in lower dose courses ... Read more

The post Many pain medications can be used for spine-related pain in older adults first appeared on Fastmediaservice.

[atom_content] =>

Journal Reference:

  1. Jonathan L. Fu, Michael D. Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & Aging, 2022; DOI: 10.1007/s40266-022-00946-x

Now a new review study has found acetaminophen is safe in older adults, but non-steroidal anti-inflammatories (ibuprofen) may be more effective for spine-related pain. Non-steroidal anti-inflammatories should be used short-term in lower dose courses with gastrointestinal precaution while corticosteroids show the least evidence for treating nonspecific back pain.

Additionally, nerve pain medications (gabapentin and pregabalin) can be used in older persons, with caution to dose and kidney function. Newer antidepressants (duloxetine) more so than older ones (nortriptyline) can help with spine-related pain, with attention to possible sedation and dizziness. Some muscle relaxants (baclofen and tizanidine) can be used in older persons, again accounting for kidney and liver function. Opioids have limited use in common spine-related pain, but can be used with caution in cases that don?t respond to treatment.

?Most older people experience neck or low back pain at some point, bothersome enough to see their doctor. Our findings provide a helpful medication guide for physicians to use for spine pain in an older population that can have a complex medical history,? explained corresponding author Michael D. Perloff, MD, PhD, assistant professor of neurology at Boston University School of Medicine (BUSM) and a neurologist at Boston Medical Center.

The researchers performed a literature review to assess the evidence-basis for medications used for spine-related pain in older adults, with a focus on drug metabolism and adverse drug reactions. They then provided their recommendations based on safe and effective dosing.

Among their findings:

According to the researchers, complementary medicine, physical therapy, injections and surgery all have a place to help older persons with spine-related pain. ?Medications used at the correct dose, for the correct diagnosis, adjusting for preexisting medical problems can result in better use of treatments for spine pain,? added first author Jonathan Fu, a 2022 MD graduate from BUSM.

These findings appear online in the journal Drugs & Aging.

Many pain medications can be used for spine-related pain in older adults

The post Many pain medications can be used for spine-related pain in older adults first appeared on Fastmediaservice.

[date_timestamp] => 1656470532 ) ) [channel] => Array ( [title] => Fastmediaservice [link] => https://fastmediaservice.com [lastbuilddate] => Wed, 29 Jun 2022 12:05:12 +0000 [language] => en-US [sy] => Array ( [updateperiod] => hourly [updatefrequency] => 1 ) [generator] => https://wordpress.org/?v=6.0 [tagline] => ) [textinput] => Array ( ) [image] => Array ( ) [feed_type] => RSS [feed_version] => 2.0 [encoding] => ISO-8859-1 [_source_encoding] => [ERROR] => [WARNING] => [_CONTENT_CONSTRUCTS] => Array ( [0] => content [1] => summary [2] => info [3] => title [4] => tagline [5] => copyright ) [_KNOWN_ENCODINGS] => Array ( [0] => UTF-8 [1] => US-ASCII [2] => ISO-8859-1 ) [stack] => Array ( ) [inchannel] => [initem] => [incontent] => [intextinput] => [inimage] => [current_namespace] => [last_modified] => Wed, 29 Jun 2022 12:29:13 GMT [etag] => kFJ7OwZh/nNw9DCD3Zuz6gg/3sY )